The testosterone and exercise study (TEX study)

Investigating the effects of testosterone and exercise on cardiovascular health

Advancing age is an unmodifiable risk factor for cardiovascular disease, and by the time men reach middle to older age, manifestations indicating the onset or presence of disease are commonly apparent.

An inverse relationship exists between age and testosterone levels, and some data suggests that low circulating testosterone may be an independent risk factor or even a predictor of vascular-event risk, which extends beyond a mere age-related phenomenon (Yeap et al., 2009).

Recent cross-sectional data found that in a group of men with type II diabetes, 31 per cent had low testosterone and in that sub-group, there was a significantly greater degree of risk factors related to vascular morphology and function compared to those with normal testosterone levels (Farias et al., 2014). In some cases, testosterone supplementation has improved cardiovascular outcomes and it is often prescribed under this premise (Handelsman, 2013).

In a low-normal testosterone research population, we are investigating what effect 12 weeks of testosterone administration or combined aerobic and resistance exercise training has on numerous outcomes of vascular function and structure. In addition, we seek to determine whether the combination of testosterone and exercise training provides any additional benefit compared to either intervention alone.

Previous research by our team has identified that regular exercise can induce improvements to vascular health. This project will help us determine what effect increasing testosterone by exogenous means has on vascular health, how it compares to exercise derived changes, and if there is justification to combine these interventions for added health benefits in those with low-normal testosterone.

Read more about our exercise research and our cardiovascular research group

Suggested readings

Research team leader: Professor Daniel John Green

I am a human integrative biologist whose research focuses on the prevention of cardiovascular diseases. My specific expertise relates to novel imaging approaches to the assessment of micro and macrovascular diseases, including surrogate measures of early and occult disease.

How to apply

Interested in becoming part of this project? Complete the following steps to submit your expression of interest:

Step 1 - Check criteria

General UWA PhD entrance requirements can be found on the Future Students website.

Step 2 - Submit enquiry to research team leader

Step 3 - Lodge application

After you have discussed your project with the research team leader, you should be in a position to proceed to the next step of the UWA application process: Lodge an application. Different application procedures apply to domestic and international students.


Scholarships specific to this project

Top-up scholarships may be available for this project. Contact the research team for details.

Domestic students

All domestic students may apply for Research Training Program and University Postgraduate Awards (UPA) scholarships

International students

A range of scholarships are available from international organisations and governments. The full list, organised by country, is available on the Future Students website.

In addition, all international students may apply for International Research Training Program scholarships.

Indigenous students
Indigenous students are encouraged to apply for Indigenous Postgraduate Research Supplementary Scholarships.
Prestigious postgraduate research scholarships

Prestigious postgraduate research scholarships support graduate research training by enabling students of exceptional research promise to undertake higher degrees by research at the University.

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