The University of Western Australia

UWA Staff Profile


Jeffrey Keelan

Professor Jeffrey Keelan

Contact details

Address School of Women's and Infants' Health
The University of Western Australia (M550)
35 Stirling Highway
CRAWLEY WA 6009
Australia
Phone 9340 1880
Fax 9381 3031

Key research

  • Inflammation-associated preterm labour
  • Anti-inflammatory modalities to prevent preterm labour
  • Fetal membrane apoptosis and premature rupture
  • Placental drug transport
  • Lipid-derived mediators in placental growth and function in pregnancy

Major research interests

  • Placental inflammation
  • Lipid-derived mediators in pregnancy
  • Pre-term birth (prevention of)
  • Placental growth, development and apoptosis
  • Placental drug transporters
  • RNA interference

Qualifications

BSc Liv., MSc PhD Auck., MRSNZ

Publications

Number of citations = 1903
h-index (Scopus) = 26 (Dec 2009)

Published peer-reviewed research papers (75)
1. JA Keelan, P-M Wong, PS Bird, MD Mitchell. Innate inflammatory responses of human decidual cells to periodontopathic bacteria. American Journal of Obstetrics & Gynecology, accepted December 2009
2. JA Keelan, S Khan, F Yosaatmadja, MD Mitchell. Prevention of inflammatory activation of human gestational membranes in an ex-vivo model using a pharmacological NF-B inhibitor. Journal of Immunology, Sep 25. Epub 2009
3. Mitchell MD, Sato TA, Wang A, Keelan JA, Ponnampalam AP, Glass M. (2008) Cannabinoids stimulate prostaglandin production by human gestational tissues through a tissue and CB1 receptor specific mechanism. Am J Physiol Endocrinol Metab. 294(2): E352-6 [Epub Nov 27 2007]
4. DA Evseenko, P Murthi, JW Paxton, G Reid, DBS Emerald, M Mohan, PE Lobie, SP Brennecke, B Kalionis, JA Keelan. (2007) The ABC transporter BCRP/ABCG2 is a placental survival factor, and its expression is reduced in idiopathic human fetal growth restriction. FASEB J, 21(13): 3592-605. [Epub 2007 Jun 26]
5. IL Aye, JW Paxton, DA Evseenko, JA Keelan (2007). Expression, localisation and activity of ATP Binding Cassette (ABC) family of drug transporters in human fetal membranes. Placenta, 28(8-9): 868-77.
6. DA Evseenko, JW Paxton, JA Keelan (2007). The xenobiotic transporter ABCG2 plays a novel role in differentiation of trophoblast-like BeWo cells. Trophoblast Research (Placenta); 21 Suppl A: S116-20.
7. DA Evseenko, JW Paxton, JA Keelan. (2007) Independent regulation of apical and basolateral drug transporter expression and function in placental trophoblasts by cytokines, steroids and growth factors. Drug Metabolism & Disposition; 35(4): 595-601.
8. Evseenko, JW Paxton, JA Keelan. (2006) ABC drug transporter expression and functional activity in trophoblast like cell lines and differentiating primary trophoblast. American Journal of Physiology: Regulation & Integrative Comparative Physiology. 290(5): R1357-65.
9. RJA Helliwell, JA Keelan, KW Marvin, L Adams, MC Chang, A Anand, TA Sato, S O’Carroll, T Chaiworapongsa, RJ Romero, MD Mitchell. (2006) Gestational age-dependent up-regulation of prostaglandin D synthase (PGDS) and production of PGDS-derived anti-inflammatory prostaglandins in human placenta. Journal of Clinical Endocrinology & Metabolism, 91: 597-606.
10. M Blumenstein, JA Keelan, JM Bowen-Shauver, MD Mitchell (2005) Suppressors of cytokine signaling (SOCS) proteins in human preterm placental tissues. Journal of Molecular Endocrinology, 35: 165-175.
11. SR Ravelich, AN Shelling, DN Wells, AJ Peterson, RSF Lee, A Ramachandran, JA Keelan. (2006) Expression of TGF-1, TGF-2, TGF-3 and the receptors TGF-RI and TGF-RII in placentomes of artificially inseminated and nuclear transfer-derived bovine pregnancies. Placenta, 27(2-3): 307-16.
12. EBE Berry, JA Keelan, RJA Helliwell, RS Gilmour and MD Mitchell (2005) Nanomolar and micromolar effects of 15-deoxy-12,14-Prostaglandin J2 on amnion-derived WISH epithelial cells: differential roles of PPAR-, – and NF-B. Molecular Pharmacology, 68: 169-178 [Epub April 8, 2005].
13. SR Ravelich, AN Shelling, A Ramachandran, S Reddy, JA Keelan, DN Wells, AJ Peterson, RSF Lee and BH Breier (2004) Altered placental lactogen and leptin expression in placentomes from bovine nuclear transfer pregnancies. Biology of Reproduction, 71(6):1862-69.
14. MD Mitchell, KL Simpson and JA Keelan. (2004) Paradoxical pro-inflammatory actions of interleukin-10 in human amnion: potential roles in term and preterm labor. Journal of Clinical Endocrinology and Metabolism. 89(9): 4149-52.
15. AC Collier, JA Keelan, PE van Zijl, JW Paxton, MD Mitchell, MD Tingle. (2004) Human placental glucuronidation and transport of 3’azido-3’-deoxythymidine (AZT) and uridine diphosphate glucuronic acid (UDPGA). Drug Metabolism and Disposition, 32(8): 813-820.
16. CA Jefferies, PL Hofman, JA Keelan, EM. Robinson, WS Cutfield. (2004) Insulin resistance is not due to persistently elevated serum tumor necrosis-alpha levels in small for gestational age, premature, or twin children. Pediatric Diabetes, 5(1): 20-5.
17. SR Ravelich, BH Breier, S Reddy, JA Keelan, DN Wells, AJ Peterson, RSF Lee. (2004) Insulin-like growth factor-I and binding proteins 1, 2, and 3 in bovine nuclear transfer pregnancies. Biology of Reproduction. 70(2):430-8. Epub 2003 Oct 15
18. JA Keelan, J Yang, RJ Romero, T Chaiworapongsa, KW Marvin, TA Sato, MD Mitchell. Epithelial cell-derived neutrophil activating peptide (ENA)-78 is present in fetal membranes and amniotic fluid at increased concentrations with intraamniotic infection and preterm delivery. (2004) Biology of Reproduction, 70(1):253-9; Epub 17 Sept 2003.
19. AC Collier, RJA Helliwell, JA Keelan, JW Paxton, MD Mitchell and MD Tingle. 3’Azido-3’-deoxythymidine (AZT) causes apoptosis and alters metabolising enzymes in human placenta: an effect enhanced by serum withdrawal. (2003) Toxicology and Applied Pharmacology 192(2):164-73.
20. JA Keelan, K Wang, MD Mitchell, RJ Romero, T Chaiworapongsa, D Brown, D Fairlie, SN Breit. Macrophage inhibitory cytokine 1 (MIC-1) in fetal membranes and amniotic fluid from pregnancies with and without preterm labour and premature rupture of membranes. (2003) Human Reproduction 9(9): 535-540
21. M Lonergan, D Oponso, KW Marvin, TA Sato, RJA Helliwell, MD Mitchell, RJ Romero, T Chaiworapongsa, JA Keelan. (2003) TNF-related apoptosis-inducing ligand (TRAIL), TRAIL receptors, and the soluble receptor osteoprotegerin (OPG) in human gestational membranes and amniotic fluid during pregnancy and labor. (2003) Journal of Clinical Endocrinology & Metabolism 88(8): 3835-3844.
22. JA Keelan, M Blumenstein, RJA Helliwell, TA Sato, KW Marvin, MD Mitchell. (2003) Cytokines, prostaglandins and parturition: A review. Placenta 24: Supplement A: Trophoblast Research 17: S33-S46.
23. CA Blackburn, JA Keelan, RS Taylor, RA North. (2003) Maternal serum activin A in women at high-risk of developing preeclampsia. American Journal of Obstetrics & Gynecology,188:807-811.
24. TA Sato, JA Keelan, MD Mitchell. (2003) Critical interactions between tumor necrosis factor-α and interleukin-10 regulate lipopolysaccharide-stimulated human choriodecidual cytokine and prostaglandin production. Journal of Immunology, 170:158-166.
25. JM Bowen, LW Chamley, MD Mitchell JA Keelan. (2002) Cytokines of the Placenta and Extra-Placental Membranes: Roles and Regulation during Human Pregnancy and Parturition. Placenta 23(4):257-273
26. JM Bowen, LW Chamley, MD Mitchell JA Keelan. (2002) Cytokines of the placenta and extra-placental membranes: biosynthesis, secretion and roles in establishment of pregnancy. Placenta 23(4):239-256
27. AC Collier, MD Tingle, JW Paxton, MD Mitchell, and JA Keelan. (2002) Xenobiotic metabolising enzymes in the first trimester human placenta: Activity, expression, localisation and effects of maternal factors. Human Reproduction, 17(10):2564-2572.
28. Blumenstein M, Mitchell MD, Groome NP and Keelan JA. (2002) Hypoxia inhibits activin A production by term villous trophoblast in vitro. Placenta, 23(10):735-741.
29. TA Sato, JA Keelan, M Blumenstein and MD Mitchell. (2002) Efficacy and specificity of non-steroidal anti-inflammatory drugs for the inhibition of cytokine-stimulated prostaglandin E2 secretion by amnion-derived WISH cells. Prostaglandins, Leukotrienes and EFA 66(5-6):525-527.
30. KW Marvin, JA Keelan, RL Eykholt, TA Sato and MD Mitchell. (2002) Expression of angiogenic and neurotrophic factors in human amnion and choriodecidua. American Journal of Obstetrics and Gynecology, 187(3):728-734.
31. M Blumenstein, JM Bowen-Shauver, JA Keelan and MD Mitchell. (2002) Identification of suppressors of cytokine signaling (SOCS) proteins in gestational tissues: Differential regulation is associated with the onset of labour. J Clin Endocrinol Metab, 87(3):1094-1097.
32. AC Collier, NA Ganley, MD Tingle, M Blumenstein, MD Mitchell, JW Paxton and JA Keelan. (2002) UDP-glucuronosyltransferase activity, expression and cellular localization in human placenta at term. Biochemical Pharmacology, 63(3):409-412.
33. KW Marvin, JA Keelan, RL Eykholt, TA Sato, and MD Mitchell. (2002) Use of cDNA arrays to generate differential expression profiles for inflammatory genes in human gestational membranes delivered at term and preterm. Molecular Human Reproduction, 8(4):399-408.
34. JA Keelan, R Taylor, J-C Schellenberg NP Groome, MD Mitchell and Robyn A North. (2002) Serum activin A, inhibin A and follistatin concentrations in women with preeclampsia or idiopathic small for gestational age pregnancies. Obstet Gynecol, 99(2):267-274
35. JA Keelan, RJ Helliwell, BE Nijmeijer, EBE Berry, TA Sato, MD Mitchell and RS Stewart (2001) 15-deoxy-12,14-prostaglandin J2 - induced apoptosis in amnion-derived WISH cells. Prostaglandins and Other Lipid Mediators 66(4):265-282.
36. TA Sato, JA Keelan, and MD Mitchell. (2002) Regulation of prostaglandin production in an immortalized human myometrial cell line by cytokines and non-steroidal anti-inflammatory drugs. Eur J Obstet Gynecol Reprod Biol. 100(2):158-162.
37. TA Sato, DK Gupta, JA Keelan, KW Marvin and MD Mitchell. (2001) Expression of IL-1 in murine intrauterine tissues: relationship with gestational age. American Journal of Reproductive Immunology 46(6):413-419.
38. TA Sato, DK Gupta, JA Keelan, KW Marvin, and MD Mitchell. (2001) Cytosolic phospholipase A2 and 15-hydroxyprostaglandin dehydrogenase mRNA expression in murine uterine and gestational tissues during late pregnancy. Prostaglandins Leukot Essent Fatty Acids. 64(4-5):247-51.
39. M Blumenstein, JA Keelan and MD Mitchell. (2001) Hypoxia attenuates PGE2 but increases prostacyclin and thromboxane production in human term villous trophoblast. Placenta, 22(6):519-25
40. DK Gupta, TA Sato, JA Keelan, K.W Marvin and MD Mitchell. (2001) Expression of Type I and II isoforms of prostaglandin H synthase in murine uterine and intrauterine tissues during normal pregnancy. Prostaglandins and Other Lipid Mediators, 66(1):17-25.
41. TA Sato, DK Gupta, JA Keelan, KW Marvin and MD Mitchell. (2001) Gestational age-dependent effects of lipopolysaccharide on prostaglandin production by murine decidual caps. Prostaglandins Leukot Essent Fatty Acids 64(2):135-138.
42. MAG Coleman, JA Keelan, LME McCowan, K Townend & MD Mitchell. (2001) Predicting preterm delivery: Comparison of cervicovaginal interleukin (IL)-1, IL-6, IL-8, IL-10, and tumor necrosis factor- with fetal fibronectin and cervical dilatation. Eur J Obstet Gynaecol Reprod Dev 95(2) 154-158.
43. JA Keelan, R-L Zhou, LW Evans, NP Groome & MD Mitchell. (2000) Regulation of activin A, inhibin A and follistatin production in human amnion and choriodecidual explants by inflammatory mediators. J Soc Gynecol Invest 7(5):291-296.
44. AC Collier, MD Tingle, JA Keelan, JW Paxton, MD Mitchell. (2000) A highly sensitive fluorescent microplate method for the determination of UGT activity in cell lines and tissues. Drug Metabolism and Disposition 28(10):1984-1986.
45. MAG Coleman, JT France, J-C Schellenberg, V Ananiev, K Townend, JA Keelan, NP Groome and Lesley ME McCowan. (2000) Corticotrophin releasing hormone (CRH), CRH binding protein and activin-A in maternal serum: Prediction of preterm delivery and response to glucocorticoids, in women with symptoms of preterm labor. Am J Obstet Gynecol. 183: 643-648.
46. KW Marvin, JA Keelan, TA Sato and MD Mitchell. (2000) The 15-deoxy-12,14-prostaglandin J2 receptor, peroxisome proliferator activated receptor- (PPAR-) is expressed in gestational tissues and is functionally active in JEG3 choriocarcinoma cells. Placenta 21:436-440.
47. KW Marvin, JA Keelan, MAG Coleman, LME McCowan, R-L Zhou, and MD Mitchell. (2000) Intercellular adhesion molecule-1 (ICAM-1) in cervicovaginal fluid of women presenting with preterm labor: predictive value for preterm delivery. Am J Reprod Immunol. 43:264-271.
48. EBE Soh, MD Mitchell and JA Keelan (2000). Does leptin exert cytokine-like effects in tissues of pregnancy? Am J Reprod Immunol. 43:292-298.
49. MD Mitchell, V Goodwin, S Mesnage and JA Keelan. (2000) Cytokine-induced coordinate expression of enzymes of prostaglandin biosynthesis and metabolism: 15-hydroxyprostaglandin dehydrogenase. Prostaglandins Leukotrienes EFA. 62(1):1-5.
50. KW Marvin, JA Keelan, TA Sato, MAG Coleman, LME McCowan and MD Mitchell. (1999) Expression of intercellular adhesion molecule-1 (ICAM-1) in choriodecidua with labour and delivery at term and preterm. Reprod Fertil Dev 11:255-262.
51. A Keelan, TA Sato, DK Gupta, KW Marvin, and MD Mitchell. (2000) Prostanoid stimulation of cytokine production in an amnion-derived cell line: evidence of a novel feed-forward mechanism with implications for term and preterm labor. J Soc Gynecol Invest 7: 37-44.
52. JA Keelan, R-L Zhou, MD Mitchell. (2000) Activin A exerts both pro- and anti-inflammatory effects on human term gestational tissues. Placenta 21(1): 38-43.
53. S Potter, WR Hansen, JA Keelan, MD Mitchell. (2000) Characterization of the amnion-derived AV3 cell line for use as a model for investigation of prostaglandin-cytokine interactions in human amnion. Prostaglandins, Leukotrienes, EFA. 61(6): 373-379.
54. KW Marvin, JA Keelan, TA Sato, MAG Coleman, LME McCowan, HC Miller and MD Mitchell. (2000) Enhanced expression of intercellular adhesion molecule-1 (ICAM-1) in amnion with term and preterm labor. Placenta 21(1): 115-121.
55. JA Keelan, KW Marvin, TA Sato, LME McCowan, MAG Coleman, LW Evans, N P Groome & M D Mitchell. (1999) Cytokine abundance in intrauterine tissues: Evidence of inflammatory activation in gestational membranes with term and preterm parturition. Am J Obstet Gynecol. 181(6): 1530-6
56. JA Keelan, KW Marvin, TA Sato, LME McCowan, MAG Coleman, LW Evans, N P Groome & M D Mitchell. (1999) Concentrations of activin-A, inhibin-A and follistatin in human amnion, choriodecidual and placental tissues at term and preterm. J Endocrinol. 163: 99-106.
57. JA Keelan, TA Sato, KW Marvin, J Lander, S Gilmour and MD Mitchell. (1999) 15-deoxy-12,14-prostaglandin J2, a ligand for peroxisome proliferator-activated receptor, induces apoptosis in JEG3 choriocarcinoma cells. Biochem Biophys Res Comm, 262(3): 579-585.
58. JA Keelan, TA Sato, WR Hansen, JS Gilmour, NA Helsby & MD Mitchell. (1999) Interleukin-4 (IL-4) differentially regulates prostaglandin production in amnion-derived WISH cells stimulated with pro-inflammatory cytokines and epidermal growth factor. Prostaglandins, Leukotrienes and Essential Fatty Acids, 60(4):255-262.
59. KL Simpson, JA Keelan, MD Mitchell. (1999) Labor-associated changes in the regulation of production of immunomodulators in human amnion by glucocorticoids, bacterial lipopolysaccharide and pro-inflammatory cytokines. J Reprod Fertil, 116:321-327.
60. WR Hansen, A Drew, N Helsby, JA Keelan, TA Sato, and MD Mitchell. (1999) Regulation of cytosolic phospholipase A2 expression by cytokines in human amnion cells. Placenta, 20(4):303-308.
61. JA Keelan, TA Sato & MD Mitchell. (1998) Comparative studies on the effects of interleukin (IL)-4 and IL-13 on cytokine and prostaglandin E2 production by amnion-derived WISH cells. Am J Reprod Immunol 40(5):332-338.
62. VJ Goodwin, T Sato, MD Mitchell and JA Keelan. (1998) Anti-inflammatory effects of interleukin-4 (IL-4), IL-10 and transforming growth factor- on human placental cells in vitro. Am J Reprod Immunol, 40(5):319-325.
63. JS Gilmour, WR Hansen, HC Miller, JA Keelan, TA Sato, & MD Mitchell (1998) Effects of interleukin-4 on the expression and activity of prostaglandin endoperoxide H synthase-2 in amnion-derived WISH cells. J Mol Endocrinol 21(3):317-325.
64. KL Simpson, JA Keelan, MD Mitchell. (1998) Labor-associated changes in interleukin-10 (IL-10) production and its regulation by immunomodulators in human choriodecidua. J Clin Endo Metab 83(12): 4332-4337.
65. JA Keelan and MD Mitchell (1998) The effects of a ceramide analog, N-acetylsphingosine, on basal and tumour necrosis factor--stimulated production of prostaglandins and cytokines in gestational tissues Prostaglandins and other Lipid Mediators, 55:141-158.
66. JA Keelan, NP Groome, and MD Mitchell (1998) Regulation of activin-A production by human amnion, decidua and placenta in vitro by pro-inflammatory cytokines. Placenta, 19:429-434.
67. JA Keelan, T Sato and MD Mitchell. (1997) Regulation of interleukin (IL)-6 and IL-8 production in an amnion-derived cell line by cytokines, growth factors, glucocorticoids and phorbol esters. Am J Reprod Immunol, 38(4):272-278.
68. M Walton, E Sirimanne, C Williams, PD Gluckman, JA Keelan, MD Mitchell and M Dragunow. (1997) Prostaglandin H synthase-2 and cytosolic phospholipase A2 in the hypoxic-ischemic brain: role in neuronal death or survival? Mol Brain Res 50:165-170.
69. JA Keelan, T Sato and MD Mitchell (1997) Interleukin (IL)-6 and IL-8 production by human amnion cells in vitro: Regulation by cytokines, growth factors, glucocorticoids, phorbol esters and bacterial lipopolysaccharide. Biol Reprod, 57:1438-1444.
70. Y Song, JA Keelan, and JT France (1996) Activin-A stimulates, while transforming growth factor- inhibits, chorionic gonadotrophin production and aromatase activity in cultured human placental trophoblasts. Placenta, 17: 603-610.
71. JT France, JA Keelan, L Song, H Liddell, A Zanderigo & BS Knox (1996) Serum concentrations of human chorionic gonadotrophin and immunoreactive inhibin in early pregnancy and recurrent miscarriage: a longitudinal study. Aust NZ J Obstet Gynaecol, 36: 325-330.
72. D Simmons, JT France, JA Keelan, L Song and BS Knox. (1994) Sex differences in serum levels of inhibin and other sex hormones in human umbilical cord blood. Biol Neonate 65: 287-94.
73. JA Keelan, Y Song and JT France (1994) Comparative regulation of inhibin, activin and hCG production by placental trophoblast cells in culture. Placenta, 115: 803-818.
74. JA Keelan, JT France and PM Barling (1987) An alternative fluorescence enhancement solution for use in lanthanum-based time-resolved fluoroimmunoassays. Clin Chem, 33: 2292-2295.
75. JT France, W Jackson, and JA Keelan. (1986) A radioimmunoassay for plasma dehydro-epiandrosterone sulphate incorporating placental steroid sulphatase as a hydrolysing reagent. J Steroid Biochem, 25(3):375-378.

Book chapters (6):

JA Keelan, MD Mitchell. Placental cytokines and preeclampsia. Front Biosci. 2007 Jan 1;12:2706-27.

MD Mitchell and JA Keelan (2006) Inflammation and Normal Labour. In: Inflammation and Pregnancy, Peebles & Myatt, Eds. Taylor & Francis medical Books, London

JA Keelan, RJA Helliwell, LF Adams, KW Marvin, TA. Sato and MD. Mitchell (2005) Prostaglandin E Synthases in Late Pregnancy and Parturition: Location, Location and Re-location. Progress in Prostaglandin Research. Invited review in preparation.

JA Keelan, MD Mitchell, AC Collier (2004) Placental Pharmacology of the Anti-Retroviral Drug Zidovudine. In: Recent research developments in drug metabolism and disposition. Transworld Research Network, Kerali, India (Invited review)

JA Keelan. L Myatt and MD Mitchell (1997) The Endocrinology and Paracrinology of Parturition. In: Preterm Labour; MG Elder, RF Lamont, and R Romero, eds. Churchill Livingstone Press, London. 457-491.

JA Keelan, M Coleman and MD Mitchell (1997) The molecular mechanisms of term and preterm labour: recent progress and clinical implications. In: Dystocia; DJ Dudley, ed. Clinical Obstetrics and Gynecology, Lippencott-Raven Publishers, USA. 460-478.

Reviews & Editorials (11):

1. GE Lash, GJ Burton, LW Chamley, VL Clifton; MConstancia, IP Crocker, Vi Dantzer, G Desoye, S Drewlo, Denise G Hemmings, St Hiendleder, BKalionis, JA Keelan, Y Kudo, RM Lewis, U Manuelpillai, P Murthi, D Natale, C Pfarrer, S Robertson, R Saffery, S Saito, A Sferruzzi-Perri, L Sobrevia, BJ Waddell, CT Roberts. IFPA Meeting 2009 Workshops Report (Trophoblast Research) Placenta in press
2. ILMH Aye, AT Singh, JA Keelan (2009) Mini-review: Transport of lipids by ABC proteins: Interactions and implications for cellular toxicity, viability and function. Chemico-Biological Interactions, 180(3):327-39. Epub 2009 May 6.
3. K Shiverick, K Ino, T Harada, JA Keelan, F Kikkawa. (2007) Placental enzymes and transporters: New functions and genetic polymorphisms - a workshop report. (Trophoblast Research) Placenta; 28 Suppl A:S125-8. Epub 2007 Mar 26.
4. D. Evseenko, JW Paxton, JA Keelan (2006) Transport across the placenta: impact on drug efficacy and toxicity (invited review). Expert Opinion on Drug Metabolism and Toxicology, 2(1): 51-69.
5. JA Keelan and MD Mitchell (2005) Cytokines, hypoxia, and preeclampsia (invited editorial). Journal of the Society for Gynecologic Investigation 12(6): 385-7.
6. MR Syme, JW Paxton, JA Keelan. (2004) Drug metabolism and transfer by the human placenta. Clinical Pharmacokinetics; 43(8):487-514.
7. JA Keelan, M Blumenstein, RJA Helliwell, TA Sato, KW Marvin, MD Mitchell. (2003) Cytokines, prostaglandins and parturition (invited review). Placenta 24: Supplement A: Trophoblast Research 17: S33-S46.
8. JM Bowen, LW Chamley, MD Mitchell JA Keelan. (2002) Cytokines of the Placenta and Extra-Placental Membranes: Roles and Regulation during Human Pregnancy and Parturition (invited review). Placenta 23(4):257-273
9. JM Bowen, LW Chamley, MD Mitchell JA Keelan. (2002) Cytokines of the placenta and extra-placental membranes: biosynthesis, secretion and roles in establishment of pregnancy (invited review). Placenta 23(4):239-256
10. WR Hansen, JA Keelan, SJM Skinner and MD Mitchell. (1999) Key enzymes of prostanoid biosynthesis and metabolism: Coordinate regulation of expression by cytokines in gestational tissues: A review. Prostaglandins and other Lipid Mediators, 57:243-257.
11. JA Keelan and MD Mitchell (1997) Cytokines, inflammation and premature delivery. New Zealand Science Monthly, June; 8-10.

Roles, responsibilities and expertise

Director, Women's and Infants' Health Research Laboratories.
Acting Director, Women's and Newborn Health Research Network, King Edward Memorial Hospital, Perth, WA.
Associate Editor, Reproduction Fertility and Development.
Editorial Board Member, Trophoblast Research.
Expertise: Immunoassay; placental cell culture; tissue perfusion; lipid analysis; cell signaling; apoptosis and cell viability; proteomics; microarrays; real-time PCR, RNA interference

Future research

Sphingolipids in placental differentation and survival; bioactive lipid mediators from omega-3 fatty acid metabolism; innate immune system in fetal membranes; nanoparticulate drug delivery systems and placental transfer.

Funding received

HRC (NZ); March of Dimes Foundation(USA); Maurice and Phyllis Paykel Trust (NZ); AMRF (NZ); Lottery Health (NZ); Bartholomew trust; NHMRC; Raine Foundation; Australian Dental Research Foundation.

Languages

English

Memberships

ANZPRA (president); Royal Society of New Zealand (Member); Society for Reproductive Biology (Member); New Zealand Society for Endocrinology (Member and Auckland rep); Society for Gynecologic Investigation (Member); Faculty 1000 (Reproductive physiology); PSANZ (WA)

Honours and awards

Winner of the 1991 Abbott Award given at the AGM of the NZACB (New Zealand Association of Clinical Biochemists).
Winner, Shering award, New Zealand Society of Endocrinology
Nancy Sirrett Lecturer (NZSE) 2007
Invited member, Faculty of 1000 Biology, July 2007

Previous positions

Senior Lecturer, Liggins Institute and Department of Pharmacology 7 Clinical Pharmacology, University of Auckland, New Zealand

Teaching

MEDSCI201 (Introduction to Pharmacology and Toxicology): Lecturer and course coordinator.
MEDSCI720 (Biomedical research techniques) lecturer and course coordinator.
Other lecturing: Molecular Pharmacology; Reproductive biology; Placental pharmacology

Current external positions

Associate member, Liggins Institute, Auckland.
Acting Director, Women's and Newborn Health Research Network, KEMH, Perth WA.

Current projects

Contact Jeff Keelan for details

Research profile