Sarcomas are a relatively rare but aggressive form of cancer that, despite accounting for 10% of all cancers in the 15 to 25 age group, receives less than 1% of cancer research funding worldwide.
After being diagnosed with Ewings’s Sarcoma at the age of 17, Abbie Basson passed away 27 months later, just weeks after her 20th birthday.
The Abbie Basson Sarcoma Foundation was her wish and legacy, with a rallying cry of “Sock it to Sarcoma!” inspired by her simple idea of selling socks to fund vital research, provide patient support and raise awareness. Now, the foundation, relying on strong community support, has bolstered the development of multiple researchers, projects and teams specialising in sarcoma by providing PhD top-up scholarships, grants and support. These PhD students are kick-starting their research careers to make a difference for the outcomes and diagnoses of sarcoma patients.
One of the major teams focusing on sarcoma is the The Kids Research Institute Australia Sarcoma Translational Research group, led by UWA Adjunct Associate Professor Joost Lesterhuis, which aims to develop safer, more effective treatments. Two recipients of the Abbie Basson Sarcoma Research Scholarship (top up) currently work within this team.
Mr Francois Rwandamuriye (MInfectDis '15) joined the group in 2019, to undertake a project focused on tumour immunology.
His interest in the field began after looking into the specific treatments and therapies available for sarcoma patients, and their poor response rates.
After reviewing the literature, I came to notice that sarcoma therapies have not changed for the last decade! I was alarmed by the fact that this type of cancer, although rare in adults (< 1%), makes up 15% of paediatric cancer and 10% of cancers in the 15-25 age group.
Mr Francois Rwandamuriye
Although treatments are available for this rare cancer, such as chemo and radiotherapy, and surgical removal of soft-tissue sarcomas, many patients relapse; this motivated Francois to pursue safer, more effective therapies.
“Surgery is the main treatment option for soft tissue sarcoma. However, during surgery, if even one cancerous cell gets left behind there is a chance the tumour will regrow, and many patients do suffer from local relapse of their sarcoma. My research project aims to tackle this key problem.”
Also working on sarcoma relapse prevention is Ms Breana Vitale (nee Weston), who began her project in 2020, and is targeting the tumour microenvironment after surgery to prevent the relapse of soft tissue sarcoma.
2018 recipient Ms Jun (Stella) Lu is working on a different aspect of sarcoma with orthopaedic surgery researcher Professor David Wood, and cell signalling expert Associate Professor Evan Ingley. She is investigating the transformation of sarcoma into malignant forms. Associate Professor Ingley was himself an early beneficiary of an Abbie Basson Sarcoma Foundation grant, for his project examining how sarcoma cells spread and chemosensitivity of sarcoma cells derived from patient tissue.
Regenerative biology expert Winthrop Professor Jiake Xu has also just been awarded a grant for his project “Investigation of novel therapeutic inhibitors of an angiogenic factor to inhibit osteosarcoma”.
The Foundation also offers the Sock it to Sarcoma! PhD Top-up Scholarships, which are co-funded with the university. These scholarships have enabled two more research students to continue their work in the field.
Emel Rothzerg BBiomedSc (Hons) ’19 is partway through her PhD project, “Discovering molecular functions of LEPROT in osteosarcoma by combining bioinformatics and molecular genetics.” This project builds on a number of projects relating to sarcoma to which Ms Rothzerg has been integral.
Community pharmacist Ms Shahama Taifour MBiomedSc ’19, working with Associate Professor Pilar Blancafort at the Harry Perkins Institutes Laboratory of Cancer Epigenetics, is focusing on an epigenetic tool, which may lead to improving the treatment of Ewings sarcoma. Also beginning research with Associate Professor Pilar Blancafort is Graduate Research Assistant, Ash Tie BSc (Hons) ‘08. Ash has recently been awarded an Abbie Basson Sarcoma Research Scholarship and is preparing her candidacy proposal for sarcoma research.
With more than $110,000 provided this year alone to rising research stars thanks to the Abbie Basson Sarcoma Foundation, Mr Rwandamuriye is excited about the future of treatment;
"These scholarships focus on supporting the next generation of bright young cancer researchers and are very important in helping researchers to discover new, safer and more effective therapies for sarcoma."