Thesis: Neurochemical effects of repetitive Transcranial Magnetic Stimulation (rTMS) in animal models: impact on neuroplasticity and behaviour.
Non-invasive brain stimulatory tools such as repetitive Transcranial Magnetic Stimulation (rTMS) in combination with behavioural tasks have shown the potential to induce neuroplasticity and facilitate outcomes of rehabilitation in patients affected by neurological disorders. To elucidate the underlying mechanisms from the molecular to behavioural level, in vivo and in vitro studies are extremely valuable.
My project aims to investigate the neuromodulatory and neurochemical effects of 'online' rTMS on in vivo models of healthy and abnormal brain structure and function using techniques in histology and classical behavioural paradigms. In addition, effects on catecholamine systems during and after rTMS, with a particular emphasis on dopamine, will be investigated using a combination of histology, electrophysiology and liquid-chromatography coupled with mass spectrometry.
Why my research is important
The purpose of my project is to improve our current understanding of rTMS mechanisms, relating brain to behavioural changes, which will improve future translation to the clinic.