Postgraduate Profiles

Nikki Man

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Thesis: The investigations into the synthesis and biological mode of action of novel antibacterial agents.

The main aim of this project will be to establish a pharmacological study for a novel antibacterial compound, defining parameters such as susceptibility to pathogenic organisms, its structure-activity relationship and its mechanism of action.

Why my research is important

A major public health problem that our society is currently facing is the growing trend in antimicrobial resistance. It has been documented that the percentage incidence of methhicillin-resistant Staphylococcus aureus (MRSA) infections has increased from 5% in 1980 to 50% in 2000.[1] This pandemic is placing significant pressure on health care systems around the world [2] as infections caused by these pathogens are causing increased levels of morbidity and mortality than observed in the past century.[3] Due to increasing antimicrobial resistance, the number of currently available antimicrobial treatment choices for more serious bacterial infections is steadily decreasing.

References:

[1] Schmidt, M., Beyond Antibiotics: Strategies for Living in a World of Emerging Infections and Antibiotic-Resistant Bacteria, North Atlantic Books: (2009).

[2] Theuretzbacher, U., International journal of antimicrobial agents, (2012) 39, 295.

[3] Projan, S. J.; Bradford, P. A., Curr. Opin. Microbiol., (2007) 10, 441.

Funding

Jan 2013

Aug 2016

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