Thesis: The effects of a home-based exercise programme during treatment on physiological and psychosocial outcomes in patients with lymphoma.
This research aims to investigate the possible deleterious effects of high dose chemotherapy (HDC) and autologous stem cell transplants (ASCT), and assess the efficacy of a home-based exercise program implemented during treatment in patients with lymphoma treated with HDC and ASCT, compared to ‘usual care’, on the physiological and psychosocial outcomes that can possibly negatively impact the health status of patients. Outcome measures will include aerobic fitness, body composition, quality of life, blood markers, strength, physical activity levels, fatigue and symptom distress, which are currently not well understood in this population.
Why my research is important
The consequences of cancer treatment are severe and potentially long-lasting. Patients may suffer various physiological and psychosocial symptoms of distress during treatment and for a long period thereafter. Loss of physical function and fatigue may impose on the patient’s ability to return to work and perform usual activities of daily living. In addition to this, treatment of cancer has improved and more patients are surviving and living longer post-treatment. It is for these reasons that further research is required to develop optimal strategies to improve function and QoL in cancer patients. The effect of exercise as one of these strategies has been previously studied in patients with numerous types of cancer conditions, with positive results. However, literature regarding haematological malignancies treated with HDC and ASCT is limited.