Characterising, recording and supporting our unique biodiversity
Living on an island continent, Australian biota have evolved in isolation, which has given rise to Australia's unique biodiversity. All three lineages of mammals are found on the continent including monotremes (egg-laying), marsupials (pouched) and eutherians (placental) (Woinarski et al., 2015). Monotremes were the earliest diverging mammalian lineage and it is estimated marsupials and eutherians diverged ~150mya. Marsupials have a unique biology, giving birth to extremely under-developed young and having a complex lactation system. Genomic studies of marsupials are limited compared to eutherians. However, given their phylogenetic position and unusual biological features, genomic studies of marsupials have provided important insights into mammalian evolution, disease and development.
Remarkably, it is approximated that 87% of Australian terrestrial mammals are endemic. However, Australia has one of the highest recent rates of mammalian extinction in the world. Since European settlement over 10% of the 273 endemic terrestrial mammals have become extinct, with particularly high losses of marsupial species. A major driver of the decline of Australian mammals is thought to be the introduction of non-native species (Woinarski et al., 2015).
Contribute significantly to conservation of ecosystems under rapid environmental change, with unique 3D genomics to complete chromosome-genome assemblies critical for gene regulation studies, the key to understanding all species – plants, animals
Develop an integrated system for data production and analysis and train scientific leaders with diverse skillsets that blend biology, applied mathematics, computational linear algebra and algorithm design
Accelerate fundamental research with genomics to meet critical needs of conservation management of biodiversity, as identified by society, government and industry
As part of this project, the successful PhD applicant will:
Facilitate chromosome level genome assemblies across tree of life
I'm currently leading an innovative Translational Genomics research program that aims to translate fundamental science into ready-to-use solutions across the agricultural and medical sectors. My DNA Lab team enables research to span the spectrum of scientific activities beyond the traditional ‘Lab-to-Landscape’ model, using new age technologies such as CRISPR, single-cell and 3D genomics. With DNA Zoo Australia I'm on a mission to provide genomic empowerment to unique Australian biodiversity facilitating conservation efforts for the threatened and endangered species.
DNA Zoo is a watershed initiative, leading the world in rapid generation and release of high-quality genomic resources. DNA Zoo Australia at The University of Western Australia is the lead Australian node of a global project, the DNA Zoo consortium. The DNA Zoo consortium was founded as a not-for-profit organization on Nov 2nd, 2018 at Houston, TX, USA, with UWA as the lead Australian node established on 4th June 2019.
Globally >60 collaborating partners across 9 countries!
We welcome new collaborations and sharing the platform developed!
How to Apply
To be accepted into the Doctor of Philosophy, an applicant must demonstrate they have sufficient background experience in independent supervised research to successfully complete, and provide evidence of English language proficiency
Requirements specific to this project - Advanced molecular biology OR bioinformatics skills are required
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