PROJECT

Tackling carbohydrate-processing enzymes head on

Developing new scaffolds to inhibit carbohydrate-processing enzymes involved in human health and wellbeing

The enzymes that regulate the structures of glycans are extremely important and have been implicated in a wide variety of diseases and thus are targets for therapeutics. Our laboratory studies a wide variety of enzymes found in humans that have been implicated in cancer, Alzheimer’s disease, carbohydrate metabolism dysfunction and neurological diseases, as well as those in bacteria and microbes involved in antibiotic resistance and correct digestion.

Project(s) described here will be to design and synthesize new inhibitor scaffolds and various chemical tools that can be used to investigate the role these carbohydrate-processing enzymes play in the various human diseases and bacterial pathogenesis and life cycle. The prepared compounds will be tested for their potency against the enzymes in question and will be tested in vitro to determine their effectiveness at the cellular level.

Through strong international collaborations with researchers in Canada and the United Kingdom (opportunities to travel to institutions in these countries is encouraged), these compounds will also be co-crystallised with proteins of interest.

If you are excited about interdisciplinary science, enjoy experimental research in chemistry and/or biochemistry and are interested please contact me. Please note that the projects are not exhaustive and many under this theme are available. All projects will be tailored to your scientific interests.

For more background information, see the suggested readings below.

Project goals

Address the development of chemical tools using novel methodologies, both organic and biological

Evaluate the effectiveness of such tools using molecular modelling, enzyme kinetics and protein chemistry

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Use these tools to identify new, and learn how, carbohydrate-based enzymes are involved in biological systems

Research team leader: Associate Professor Keith Stubbs

I completed my undergraduate and PhD studies at UWA, followed by postdoctoral studies at Simon Fraser University in Vancouver, Canada. I am currently a Research Associate Professor and head of the GlycoPlus laboratory. My research interests are synthetic chemistry, carbohydrate chemistry and glycobiology.

PhD opportunities

Interested in becoming part of this project? Complete the following steps to submit your expression of interest:

Step 1 - Check criteria

General UWA PhD entrance requirements can be found on the Future Students website.

In addition applicants need to demonstrate adequate research by showing:

  • experience with organic chemistry
  • experience in biochemistry (desired but not essential)

The level of experience required will depend on the project involved.

Step 2 - Submit enquiry to research team leader

Step 3 - Lodge application

After you have discussed your project with the research team leader, you should be in a position to proceed to the next step of the UWA application process: Lodge an applicationDifferent application procedures apply to domestic and international students.

Scholarships

External collaborators

  • Professor David Vocadlo, Simon Fraser University
  • Professor Gideon Davies, University of York
  • Dr Brian Mark, University of Manitoba
  • Dr Alisdair Boraston, University of Victoria
  • Dr Sean Sweeney, University of York
  • Dr Elizabeth Ficko-Blean, French National Center for Scientific Research

Researchers interested in collaborating on this project are encouraged to contact the research team leader.

CRICOS Code: 00126G
Updated
Monday, 22 October 2018 9:10 AM (this date excludes nested assets)
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