The University of Western Australia
Professor Miranda Grounds
Professor
Contact details
| Address | Anatomy and Human Biology The University of Western Australia (M309) 35 Stirling Highway CRAWLEY WA 6009 Australia |
|---|---|
| Phone | 6488 3486 |
| Fax | 6488 1051 |
| miranda.grounds@uwa.edu.au | |
| Personal homepage | http://school.anhb.uwa.edu.au/PersonalPages/Grounds/default.htm |
Biography
For over 30 years, the research of M Grounds has focussed on factors controlling the repair of damaged skeletal muscle and on potential treatments for muscle diseases such as Duchenne’s muscular dystrophy, with a focus on in vivo studies and tissue analyses. Her research has pioneered many studies into factors controlling skeletal muscle regeneration with a particular emphasis on myogenesis in post-natal skeletal muscle in vivo, and an ongoing interest in the role of the extracellular matrix. Research on cell therapies developed the Y-chromosome probe for tracking male nuclei and identified the massive and rapid death of injected donor cells in Myoblast Transfer Therapy. Other projects investigate stem cell therapies (MG published the first bone-marrow reconstitution experiments to look for bone-marrow derived muscle stem cells in 1983) and Tissue Engineering for skeletal and cardiac muscle. Current research includes the in vivo role of IGF-1 isoforms, a focus on inflammation and anti-cytokine therapies, and metabolism, all with applications to muscle wasting with ageing and muscular dystrophy.
Key research
- Skeletal muscle repair; the role of growth factors and extracellular matrix components; Cell and gene therapy for muscle diseases
Major research interests
- Muscular dystrophy
- Factors affecting necrosis and repair of skeletal muscle
- Cell and gene therapy for muscle diseases
- Muscle wasting due to ageing, disease, cachexia or disuse
- Muscle hypertrophy
- Myoblasts and stem cells
- Anti-cytokine therapies
- Cell and molecular biology
- Developmental biology
- Extracellular matrix
- Growth factors
- Inflammation
- Oxidative stress
Qualifications
BSc W.Aust., PhD Lond.
Publications
Hodgetts S, Radley H, Davies M, Grounds MD. Reduced necrosis of dystrophic muscle by depletion of host neutrophils or blockading TNFa function with Etanercept in mdx mice. Neuromuscular Disorders. Accepted.
Han R, Grounds MD, Bakker AJ. (2006) Measurement of sub-membrane [Ca2+] in adult myofibers and cytosolic [Ca2+] in myotubes from normal and mdx mice using the Ca2+ indicator FFP-18. Cell Calcium. In press
Radley H, Grounds MD. (2006) Cromolyn administration (to block mast cell degranulation) reduces necrosis of dystrophic muscle in mdx mice. Neurobiology of Disease. In press
Shavlakadze T, White JD, Davies M, Grounds MD, Boswell JM, Burt DW, Asante EA, Tomas FM, Goddard C. (2006) Rsk?-actin/hIGF-I transgenic mice with increased IGF-I levels in skeletal muscle and blood: impact on regeneration, denervation, atrophy and muscular dystrophy. Growth Hormone and IGF Research In press. Available online http://dx.doi.org/10.1016/j.ghir.2005.11.003
Pullen T and Grounds MD. (2005) Muscle derived stem cells: Implications for effective Myoblast Transfer Therapy (International Union of Biochemistry and Molecular Biology) IUBMB Life. 57(11):731-736
Han R, Grounds MD, Bakker AJ. (2006) Measurement of sub-membrane [Ca2+] in adult myofibers and cytosolic [Ca2+] in myotubes from normal and mdx mice using the Ca2+ indicator FFP-18. Cell Calcium. In press
Radley H, Grounds MD. (2006) Cromolyn administration (to block mast cell degranulation) reduces necrosis of dystrophic muscle in mdx mice. Neurobiology of Disease. In press
Shavlakadze T, White JD, Davies M, Grounds MD, Boswell JM, Burt DW, Asante EA, Tomas FM, Goddard C. (2006) Rsk?-actin/hIGF-I transgenic mice with increased IGF-I levels in skeletal muscle and blood: impact on regeneration, denervation, atrophy and muscular dystrophy. Growth Hormone and IGF Research In press. Available online http://dx.doi.org/10.1016/j.ghir.2005.11.003
Pullen T and Grounds MD. (2005) Muscle derived stem cells: Implications for effective Myoblast Transfer Therapy (International Union of Biochemistry and Molecular Biology) IUBMB Life. 57(11):731-736
Funding received
The International Parent Project.
Association Francaise contre les Myopathies.
Muscular Dystrophy Association of America 2000.
Heart Foundation, Australia.
Meat & Livestock, Australia.
National Health and Medical Research Council of Australia.
AMRAD.
The Arnold Yeldham and Mary Raine Medical Research Foundation,UWA.
Medical Research Council of W.A.
Association Francaise contre les Myopathies.
Muscular Dystrophy Association of America 2000.
Heart Foundation, Australia.
Meat & Livestock, Australia.
National Health and Medical Research Council of Australia.
AMRAD.
The Arnold Yeldham and Mary Raine Medical Research Foundation,UWA.
Medical Research Council of W.A.
Memberships
Committees
Conference organisation.
MG has been extensively involved in organisation of about 20 Conferences. Two major initiatives that have resulted in ongoing conferences were:
Initiating (and joint Convenor with George Yeoh) of the Combined Biological Sciences conference in 1990. This is now a major annual meeting in Perth.
Member of international Steering committee for a new meeting on “Satellite cells, regeneration and skeletal muscle diseases” 1998, in Boston. Now a regular event.
Some recent Conference and Symposia organisation is indicated below.
2000 Organiser for major TERC meeting "Frontiers in Tissue Engineering: West Australian Symposium", University of Western Australia, October, 2000.
2001 Organiser “The Cottesloe Beach Muscle Symposium”, Perth, Sept., 2001
2002 Organiser for TERC “Stem cell and Tissue Engineering Symposium”, Perth, November, 2002.
2002-2007 Organiser for series of “Molecular Mechanisms of Development” Conferences, Perth. 2003; 2004; 2005, 2006, 2007.
2004 Organising Committee: Matrix Biology Society of Australia & New Zealand meeting, Rottnest, WA, Sept. 2004
2003-2004 Co-Chair of programme committee for COMBIO 2004, Perth, September 2004)
2005- Organising Committee: Austr. Neuroscience Soc. Conference, Perth, Feb. 2005
2006 Organising Committee: Focus on Microscopy,Perth, April 2006.
Membership of Societies
Australian and New Zealand Society for Cell & Developmental Biology (ANZSCDBI). President of ANZSCDB from 1996-1998.
Australian Society for Medical Research (ASMR)
Australian Society for Biochemistry & Molecular Biology (ASBMB)
Matrix Biology
World Muscle Society
Tissue Engineering Society International
Membership of Boards
Editorial
1991- 2005 Associate Editor (from 1996): Basic and Applied Myology (Unipress)
1994 - 2006) Cell Transplantation. Muscle, Bone and Cartilage section (Pergamon)
2003- Journal of Histochemistry and Cytochemistry
Other
2002- Scientific Advisory Board. Meat & Livestock (Australia) Sheep Functional Genomics Program
2003- Scientific Advisory Board. Bioheart (USA Company). www.bioheartinc.com
2006- Norwegian Parent Project: Advisory Committee.
2006- International Society of Differentiation Board Member
Conference organisation.
MG has been extensively involved in organisation of about 20 Conferences. Two major initiatives that have resulted in ongoing conferences were:
Initiating (and joint Convenor with George Yeoh) of the Combined Biological Sciences conference in 1990. This is now a major annual meeting in Perth.
Member of international Steering committee for a new meeting on “Satellite cells, regeneration and skeletal muscle diseases” 1998, in Boston. Now a regular event.
Some recent Conference and Symposia organisation is indicated below.
2000 Organiser for major TERC meeting "Frontiers in Tissue Engineering: West Australian Symposium", University of Western Australia, October, 2000.
2001 Organiser “The Cottesloe Beach Muscle Symposium”, Perth, Sept., 2001
2002 Organiser for TERC “Stem cell and Tissue Engineering Symposium”, Perth, November, 2002.
2002-2007 Organiser for series of “Molecular Mechanisms of Development” Conferences, Perth. 2003; 2004; 2005, 2006, 2007.
2004 Organising Committee: Matrix Biology Society of Australia & New Zealand meeting, Rottnest, WA, Sept. 2004
2003-2004 Co-Chair of programme committee for COMBIO 2004, Perth, September 2004)
2005- Organising Committee: Austr. Neuroscience Soc. Conference, Perth, Feb. 2005
2006 Organising Committee: Focus on Microscopy,Perth, April 2006.
Membership of Societies
Australian and New Zealand Society for Cell & Developmental Biology (ANZSCDBI). President of ANZSCDB from 1996-1998.
Australian Society for Medical Research (ASMR)
Australian Society for Biochemistry & Molecular Biology (ASBMB)
Matrix Biology
World Muscle Society
Tissue Engineering Society International
Membership of Boards
Editorial
1991- 2005 Associate Editor (from 1996): Basic and Applied Myology (Unipress)
1994 - 2006) Cell Transplantation. Muscle, Bone and Cartilage section (Pergamon)
2003- Journal of Histochemistry and Cytochemistry
Other
2002- Scientific Advisory Board. Meat & Livestock (Australia) Sheep Functional Genomics Program
2003- Scientific Advisory Board. Bioheart (USA Company). www.bioheartinc.com
2006- Norwegian Parent Project: Advisory Committee.
2006- International Society of Differentiation Board Member
Research profile
