The University of Western Australia
Res/Assoc/Prof Livia Hool
Research Associate Professor
Contact details
| Address | Physiology The University of Western Australia (M311) 35 Stirling Highway CRAWLEY WA 6009 Australia |
|---|---|
| Phone | 6488 3307 |
| Fax | 6488 1025 |
| livia.hool@uwa.edu.au |
Location
Room 1.96, Physiology Building, Crawley campus
Biography
* Gaston Bauer Cardiovascular Research Fellow, Cellular Electrophysiology Laboratory, Royal North Shore Hospital, Sydney 1991-1995
* American Heart Association Postdoctoral Fellow, Case Western Reserve University Cleveland Ohio, USA 1995-1997
* NHMRC Peter Doherty Fellow (Established Cardiovascular Electrophysiology Laboratory) Physiology, The University of Western Australia 1998-2002
* NHMRC CDA Fellow 2004 –Current
* American Heart Association Postdoctoral Fellow, Case Western Reserve University Cleveland Ohio, USA 1995-1997
* NHMRC Peter Doherty Fellow (Established Cardiovascular Electrophysiology Laboratory) Physiology, The University of Western Australia 1998-2002
* NHMRC CDA Fellow 2004 –Current
Key research
- 1. Regulation of cardiac ion channels by adrenergic receptor stimulation
- 2. Regulation of L-type Ca2+ channel function under pathological conditions such as hypoxia and oxidative stress
- 3. Role of the mitochondria and cellular redox state in the regulation of ion channel function
Major research interests
- Cardiac electrophysiology
- Membrane transport
Qualifications
BSc PhD Macq.
Publications
Hool, L.C. Hypoxia increases the sensitivity of the L-type Ca2+ channel to b-adrenergic receptor stimulation via a C2 region-containing protein kinase C isoform, Circulation Research, 87 (12): pp 1164-1171 (2000)
Hool, L.C. Hypoxia alters the sensitivity of the L-type Ca2+ channel tob-adrenergic receptor stimulation in the presence of a-adrenergic receptor stimulation, Circulation Research, 88 (10): pp 1036-1043 (2001)
Hool, L.C., Arthur, P.G. Decreasing cellular hydrogen peroxide with catalase mimics the effects of hypoxia on the sensitivity of the L-type Ca2+ channel to b-adrenergic receptor stimulation in cardiac myocytes, Circulation Research, 91: pp 601-609 (2002)
Hool, L.C. Can integrins integrate vascular myogenic responses? Circulation Research, 90 (4): pp 371-373 (2002)
Hool, L.C. Differential regulation of the slow and rapid components of guinea-pig cardiac delayed rectifier K+ channels by hypoxia, The Journal of Physiology, 554.3: pp 743-754 (2004)
Hool, L.C. Acute cellular oxygen sensing in the heart – a role for mitochondria? Vascular Disease Prevention 1: pp 197-206 (2004)
Hool, L.C. Protein kinase C isozyme selective peptides – a current view of what they tell us about location and function of isozymes in the heart, Current Pharmaceutical Design, 11 (4): pp 549-559 (2005)
Hool, L.C. Hypoxia differentially regulates K+ channels. Implications for cardiac arrhythmia, European Biophysics Journal, 34 (5): pp 369-376 (2005)
Hool, L.C., Di Maria C.A., Viola H.M., Arthur P.G. Role of NAD(P)H-oxidase in the regulation of cardiac L-type Ca2+ channel function during acute hypoxia, Cardiovascular Research, 67: pp 624-635 (2005) (Editorial on the paper published in the same issue pages 578-580).
Hool, L.C. Reactive oxygen species in cardiac signalling – from mitochondria to plasma membrane ion channels, Clinical and Experimental Pharmacology and Physiology, 33: pp 158-163 (2006)
Viola, H. M., Arthur, P.G., Hool, L.C. A transient exposure to hydrogen peroxide causes an increase in mitochondrial-derived superoxide as a result of sustained alteration in L-type Ca2+ channel function in the absence of apoptosis in adult ventricular myocytes, Circulation Research, 100: pp 1036-1044 (2007)
Hool, L.C., Corry, B. Redox control of calcium channels: from mechanisms to therapeutic opportunities, Antioxidants & Redox Signaling, 9 (4): pp 409-435 (2007)
Darrington, J., Hool L. EKG Beat analysis: minimising redundancy between detection and classification. Proc 26th IASTED International Conference on Modelling, Identification and Control 555-029, 2007 (peer reviewed) Editor: JW Gardner ISBN: 978-0-88986-648-5.
Hool L. What cardiologists should know about calcium ion channels and their regulation by reactive oxygen species. Heart Lung and Circulation, 16:361-372, 2007.
Kloda, A., Petrov, E., Myer, G.R., Nguyen, T., Hurst, A., Hool, L.C., Martinac, B. Molecules in Focus. Mechanosensitive channels of large conductance, International Journal of Biochemistry and Cell Biology 40: pp 164-69 (2008)
Hurst, A.C., Petrov, E., Kloda, A., Nguyen, T., Hool, L.C., Martinac, B. Molecules in Focus. MscS, the bacterial mechanosensitive channel of small conductance, International Journal of Biochemistry and Cell Biology, 40: pp 581-5 (2008)
Darrington J and Hool L. A new metric for the assessment of performance of heart-beat classification systems BMC Medical Informatics and Decision Making 8:7-11, 2008.
Hool L. Evidence for the regulation of L-type Ca2+ channels in the heart by reactive oxygen species – mechanism for mediating pathology, Clinical and Experimental Pharmacology and Physiology, 35: pp 229-234 (2008)
Hool, L.C. Hypoxia alters the sensitivity of the L-type Ca2+ channel tob-adrenergic receptor stimulation in the presence of a-adrenergic receptor stimulation, Circulation Research, 88 (10): pp 1036-1043 (2001)
Hool, L.C., Arthur, P.G. Decreasing cellular hydrogen peroxide with catalase mimics the effects of hypoxia on the sensitivity of the L-type Ca2+ channel to b-adrenergic receptor stimulation in cardiac myocytes, Circulation Research, 91: pp 601-609 (2002)
Hool, L.C. Can integrins integrate vascular myogenic responses? Circulation Research, 90 (4): pp 371-373 (2002)
Hool, L.C. Differential regulation of the slow and rapid components of guinea-pig cardiac delayed rectifier K+ channels by hypoxia, The Journal of Physiology, 554.3: pp 743-754 (2004)
Hool, L.C. Acute cellular oxygen sensing in the heart – a role for mitochondria? Vascular Disease Prevention 1: pp 197-206 (2004)
Hool, L.C. Protein kinase C isozyme selective peptides – a current view of what they tell us about location and function of isozymes in the heart, Current Pharmaceutical Design, 11 (4): pp 549-559 (2005)
Hool, L.C. Hypoxia differentially regulates K+ channels. Implications for cardiac arrhythmia, European Biophysics Journal, 34 (5): pp 369-376 (2005)
Hool, L.C., Di Maria C.A., Viola H.M., Arthur P.G. Role of NAD(P)H-oxidase in the regulation of cardiac L-type Ca2+ channel function during acute hypoxia, Cardiovascular Research, 67: pp 624-635 (2005) (Editorial on the paper published in the same issue pages 578-580).
Hool, L.C. Reactive oxygen species in cardiac signalling – from mitochondria to plasma membrane ion channels, Clinical and Experimental Pharmacology and Physiology, 33: pp 158-163 (2006)
Viola, H. M., Arthur, P.G., Hool, L.C. A transient exposure to hydrogen peroxide causes an increase in mitochondrial-derived superoxide as a result of sustained alteration in L-type Ca2+ channel function in the absence of apoptosis in adult ventricular myocytes, Circulation Research, 100: pp 1036-1044 (2007)
Hool, L.C., Corry, B. Redox control of calcium channels: from mechanisms to therapeutic opportunities, Antioxidants & Redox Signaling, 9 (4): pp 409-435 (2007)
Darrington, J., Hool L. EKG Beat analysis: minimising redundancy between detection and classification. Proc 26th IASTED International Conference on Modelling, Identification and Control 555-029, 2007 (peer reviewed) Editor: JW Gardner ISBN: 978-0-88986-648-5.
Hool L. What cardiologists should know about calcium ion channels and their regulation by reactive oxygen species. Heart Lung and Circulation, 16:361-372, 2007.
Kloda, A., Petrov, E., Myer, G.R., Nguyen, T., Hurst, A., Hool, L.C., Martinac, B. Molecules in Focus. Mechanosensitive channels of large conductance, International Journal of Biochemistry and Cell Biology 40: pp 164-69 (2008)
Hurst, A.C., Petrov, E., Kloda, A., Nguyen, T., Hool, L.C., Martinac, B. Molecules in Focus. MscS, the bacterial mechanosensitive channel of small conductance, International Journal of Biochemistry and Cell Biology, 40: pp 581-5 (2008)
Darrington J and Hool L. A new metric for the assessment of performance of heart-beat classification systems BMC Medical Informatics and Decision Making 8:7-11, 2008.
Hool L. Evidence for the regulation of L-type Ca2+ channels in the heart by reactive oxygen species – mechanism for mediating pathology, Clinical and Experimental Pharmacology and Physiology, 35: pp 229-234 (2008)
Funding received
NHMRC Project Grant 2006-2008
NHMRC Project Grant 2008-2011
NHMRC National Heart Foundation Biomedical Scholarship and Research Fellowship
NHMRC Project Grant 2008-2011
NHMRC National Heart Foundation Biomedical Scholarship and Research Fellowship
Teaching
PHYL3300 Mammalian Cell Biology
PHYL3350 Physiological Control Mechanisms
PHYL3350 Physiological Control Mechanisms
Current projects
PhD Students
-John Darrington- Defining algorithms to accurately detect changes in QRS Interval on ECG (Co-supervised by A/Prof Amitava Datta in the School of Computing Science)
-Helena Viola- How does the mitochondria regulate L-type calcium channel function?
-Michael Thomas- Biophysics of potassium channels (Co-supervised by Dr Ben Corry)
Graduate Diploma
Mr Kyle Yau (with Professor Nigel Laing)
Research Assistant
Ms Helen Tang
Potential Student Projects
-Which cysteines on the L-type calcium channel are modified by reactive oxygen species? (Hons/PhD level)
-How do reactive oxygen species modify the structure and function of the channel using a FRET approach? (Hons/PhD level)
Collaborators
-Professor Boris Martinac, Victor Chang Cardiac Research Institute
-Professor Nigel Laing, Western Australian Institute for Medical Research
-Dr Aleksandra Filipovska, Western Australian Institute for Medical Research
-Dr Peter Arthur, School of Biomedical, Biomolecular and Chemical Sciences, UWA
-Dr Ben Corry, School of Biomedical, Biomolecular and Chemical Sciences, UWA
-Dr Evan Ingley, Western Australian Institute for Medical Research
-Professor Yoram Rudy, Washington University, St. Louis, Missouri USA
-John Darrington- Defining algorithms to accurately detect changes in QRS Interval on ECG (Co-supervised by A/Prof Amitava Datta in the School of Computing Science)
-Helena Viola- How does the mitochondria regulate L-type calcium channel function?
-Michael Thomas- Biophysics of potassium channels (Co-supervised by Dr Ben Corry)
Graduate Diploma
Mr Kyle Yau (with Professor Nigel Laing)
Research Assistant
Ms Helen Tang
Potential Student Projects
-Which cysteines on the L-type calcium channel are modified by reactive oxygen species? (Hons/PhD level)
-How do reactive oxygen species modify the structure and function of the channel using a FRET approach? (Hons/PhD level)
Collaborators
-Professor Boris Martinac, Victor Chang Cardiac Research Institute
-Professor Nigel Laing, Western Australian Institute for Medical Research
-Dr Aleksandra Filipovska, Western Australian Institute for Medical Research
-Dr Peter Arthur, School of Biomedical, Biomolecular and Chemical Sciences, UWA
-Dr Ben Corry, School of Biomedical, Biomolecular and Chemical Sciences, UWA
-Dr Evan Ingley, Western Australian Institute for Medical Research
-Professor Yoram Rudy, Washington University, St. Louis, Missouri USA
Research profile
