The University of Western Australia
W/Prof Alan Harvey
Winthrop Professor
Contact details
| Address | Anatomy and Human Biology The University of Western Australia (M309) 35 Stirling Highway CRAWLEY WA 6009 Australia |
|---|---|
| Phone | 6488 3294 |
| Fax | 6488 1051 |
| alan.harvey@uwa.edu.au |
Biography
Born in London, UK. BA and MA from the University of Cambridge, PhD in visual neurophysiology from the Australian National University, Canberra. After time in the USA and at Flinders University in Adelaide, Alan Harvey came to UWA in 1984 and was promoted to Professor in 2001.
Key research
- Alan Harvey's research focuses on the use of cell/tissue transplantation, gene therapy and pharmacotherapy in the repair of the central nervous system (CNS), with particular emphasis on the visual system and spinal cord. He is involved in Alzheimer's disease research, and is co-leader of the Foundational Research Program, WA Centre for Excellence in Alzheimer's Disease Research and Care (2006-2008). He also has an interest in the evolution and neuroscience of music.
- He has published almost 40 papers in the last 6 years (2002-2007), including publications in the Journal of Neuroscience, Brain, Molecular Therapy, Gene Therapy, Glia, Molecular and Cellular Neuroscience, Investigative Ophthalmology and Visual Science, European Journal of Neuroscience, Neurobiology of Aging, Neuroscience and Experimental Neurology
Major research interests
- Alzheimer's disease
- Cell death
- Central nervous system development and regeneration
- Gene therapy
- Neural transplantation
- Neuroscience
- Neurotrauma and neurodegeneration
- Neurotrophic factors and cell death
- Peripheral nerve regeneration
- Regenerative neuroscience, music and human evolution
- Spinal cord injury and regeneration
- Visual system
Qualifications
MA Cantab., PhD A.N.U.
Publications
Cui, Q., Yip, H.K., Zhao, R.C.H., So, K-F. and Harvey, A.R. (2003) Intraocular elevation of cyclic AMP potentiates CNTF-induced regeneration of adult retinal ganglion cell axons. Mol. Cell Neurosci. 22: 49-61.
Yin, Y., Cui, Q., Li, Y., Irwin, N., Fischer, D., Harvey, A.R. and Benowitz, L.I. (2003) Macrophage-derived factors stimulate optic nerve regeneration. J. Neurosci., 23: 2284-2293.
Park, K., Luo, J-M, Hisheh, S., Harvey, A.R. and Cui, Q. (2004) Cellular mechanisms associated with spontaneous and ciliary neurotrophic factor/cAMP-induced survival and axonal regeneration of adult retinal ganglion cells. J. Neurosci., 24: 10806-10815.
Hu, Y., Leaver, S.G., Plant, G.W., Hendricks, W.T.J., Niclou, S.P., Verhaagen, J., Harvey, A.R. and Cui, Q. (2005) Peripheral nerve constructs genetically engineered to express CNTF enhance the regeneration of adult CNS axons. Mol. Ther., 11: 906-915.
Ruitenberg, M.J., Levison, D.B., Lee, S.V., Verhaagen, J., Harvey, A.R. and Plant, G.W. (2005) NT-3 expression from engineered olfactory ensheathing glia promotes spinal sparing and regeneration after injury. Brain, 128: 839-853.
Harvey, A.R., Hu, Y., Leaver, S.G., Mellough, C.B., Park, K., Verhaagen, J., Plant, G.W. and Cui, Q. (2006) Gene therapy and transplantation in CNS repair: the visual system. Prog. Retin. Eye Res., 25: 449-489.
Leaver, S.G., Cui, Q., Plant, G.W., Arulpragasam, A., Hisheh, S., Verhaagen, J. and Harvey, A.R. (2006) AAV-mediated expression of CNTF promotes long-term survival and regeneration of adult rat retinal ganglion cells. Gene Ther., 13: 1328-1341.
Hu, Y., Cui, Q. and Harvey, A.R. (2007) Interactive effects of C3, cyclic AMP and ciliary neurotrophic factor on adult retinal ganglion cell survival and axonal regeneration. Mol. Cell Neurosci., 34: 88-98.
Yin, Y., Cui, Q., Li, Y., Irwin, N., Fischer, D., Harvey, A.R. and Benowitz, L.I. (2003) Macrophage-derived factors stimulate optic nerve regeneration. J. Neurosci., 23: 2284-2293.
Park, K., Luo, J-M, Hisheh, S., Harvey, A.R. and Cui, Q. (2004) Cellular mechanisms associated with spontaneous and ciliary neurotrophic factor/cAMP-induced survival and axonal regeneration of adult retinal ganglion cells. J. Neurosci., 24: 10806-10815.
Hu, Y., Leaver, S.G., Plant, G.W., Hendricks, W.T.J., Niclou, S.P., Verhaagen, J., Harvey, A.R. and Cui, Q. (2005) Peripheral nerve constructs genetically engineered to express CNTF enhance the regeneration of adult CNS axons. Mol. Ther., 11: 906-915.
Ruitenberg, M.J., Levison, D.B., Lee, S.V., Verhaagen, J., Harvey, A.R. and Plant, G.W. (2005) NT-3 expression from engineered olfactory ensheathing glia promotes spinal sparing and regeneration after injury. Brain, 128: 839-853.
Harvey, A.R., Hu, Y., Leaver, S.G., Mellough, C.B., Park, K., Verhaagen, J., Plant, G.W. and Cui, Q. (2006) Gene therapy and transplantation in CNS repair: the visual system. Prog. Retin. Eye Res., 25: 449-489.
Leaver, S.G., Cui, Q., Plant, G.W., Arulpragasam, A., Hisheh, S., Verhaagen, J. and Harvey, A.R. (2006) AAV-mediated expression of CNTF promotes long-term survival and regeneration of adult rat retinal ganglion cells. Gene Ther., 13: 1328-1341.
Hu, Y., Cui, Q. and Harvey, A.R. (2007) Interactive effects of C3, cyclic AMP and ciliary neurotrophic factor on adult retinal ganglion cell survival and axonal regeneration. Mol. Cell Neurosci., 34: 88-98.
Future research
Gene therapy, transplantation and CNS repair
Funding received
Alan Harvey is funded by an NHMRC Project Grant and by the WA Neurotrauma Research Program.
Memberships
Member of
American Neuroscience Society
Australian Neuroscience Society
The International Neural Transplantation Council (1999- )
The International Programming Committee, Asia Pacific Symposia on Neural Regeneration
The International Scientific Committee, Spinal Cure Australia (2004- )
The Management Committee, WA Neurotrauma Research Programme (2003- )
Board member of:
The West Australian Neuroscience (WANS) (2005- )
The Neurological Council of WA (2004- )
American Neuroscience Society
Australian Neuroscience Society
The International Neural Transplantation Council (1999- )
The International Programming Committee, Asia Pacific Symposia on Neural Regeneration
The International Scientific Committee, Spinal Cure Australia (2004- )
The Management Committee, WA Neurotrauma Research Programme (2003- )
Board member of:
The West Australian Neuroscience (WANS) (2005- )
The Neurological Council of WA (2004- )
Current external positions
Alan Harvey is a member of: the International Neural Transplantation Council (1999- ); member of the International Programming Committee, Asia Pacific Symposia on Neural Regeneration; member of the International Scientific Committee, Spinal Cure Australia (2004- ); member of the Management Committee, WA Neurotrauma Research Programme (2003- ); Board Member of West Australian Neuroscience (WANS) (2005- ); Board Member of the Neurological Council of WA (2004- ). He was a member of the WA Reproducrtive Technology Council for 10 years, 1996-2006.
Current projects
NHMRC grant 2006-2008.
The combined use of transplantation and gene therapy techniques to promote regeneration after neurotrauma.
The combined use of transplantation and gene therapy techniques to promote regeneration after neurotrauma.
Research profile
