The University of Western Australia

UWA Staff Profile

Ipsum Lorem

Alan Harvey

W/Prof Alan Harvey

Winthrop Professor
School of Anatomy, Physiology and Human Biology

Contact details
Address
School of Anatomy, Physiology and Human Biology
The University of Western Australia (M309)
35 Stirling Highway
CRAWLEY WA 6009
Australia
Phone
6488 3294
Fax
6488 1051
Email
alan.harvey@uwa.edu.au
Qualifications
MA Camb., PhD ANU
Biography
Born in London, UK. BA and MA from the University of Cambridge, PhD in visual neurophysiology from the Australian National University, Canberra. After time in the USA and at Flinders University in Adelaide, Alan Harvey came to UWA in 1984 and was promoted to Professor in 2001.
Key research
Alan Harvey's current research focuses on the use of gene therapy, cell/tissue transplantation, nanotechnology and pharmacotherapy in the repair of the central nervous system (CNS), with particular emphasis on the visual system and spinal cord. He is also involved in Alzheimer's disease research, and was a co-leader of the Foundational Research Program, WA Centre for Excellence in Alzheimer's Disease Research and Care (2006-2008). He also has an interest in the evolution and neuroscience of music, and is beginning to publish in that field.
To date he has published over 160 scientific papers or book chapters, including publications in PNAS, Journal of Neuroscience, Brain, Molecular Therapy, Gene Therapy, ACS Nano, Progress in Retinal and Eye Research, Current Gene Therapy, Glia, Neurobiology of Aging, PLoS ONE, Molecular and Cellular Neuroscience, Investigative Ophthalmology and Visual Science, Journal of Neurotrauma, European Journal of Neuroscience, and Experimental Neurology.
Publications
Yin, Y., Cui, Q., Li, Y., Irwin, N., Fischer, D., Harvey, A.R. and Benowitz, L.I. (2003) Macrophage-derived factors stimulate optic nerve regeneration. J. Neurosci., 23: 2284-2293.

Park, K., Luo, J-M, Hisheh, S., Harvey, A.R. and Cui, Q. (2004) Cellular mechanisms associated with spontaneous and ciliary neurotrophic factor/cAMP-induced survival and axonal regeneration of adult retinal ganglion cells. J. Neurosci., 24: 10806-10815.

Hu, Y., Leaver, S.G., Plant, G.W., Hendricks, W.T.J., Niclou, S.P., Verhaagen, J., Harvey, A.R. and Cui, Q. (2005) Peripheral nerve constructs genetically engineered to express CNTF enhance the regeneration of adult CNS axons. Mol. Ther., 11: 906-915.

Ruitenberg, M.J., Levison, D.B., Lee, S.V., Verhaagen, J., Harvey, A.R. and Plant, G.W. (2005) NT-3 expression from engineered olfactory ensheathing glia promotes spinal sparing and regeneration after injury. Brain, 128: 839-853.

Harvey, A.R., Hu, Y., Leaver, S.G., Mellough, C.B., Park, K., Verhaagen, J., Plant, G.W. and Cui, Q. (2006) Gene therapy and transplantation in CNS repair: the visual system. Prog. Retin. Eye Res., 25: 449-489.

Leaver, S.G., Cui, Q., Plant, G.W., Arulpragasam, A., Hisheh, S., Verhaagen, J. and Harvey, A.R. (2006) AAV-mediated expression of CNTF promotes long-term survival and regeneration of adult rat retinal ganglion cells. Gene Ther., 13: 1328-1341.

Hu, Y., Cui, Q. and Harvey, A.R. (2007) Interactive effects of C3, cyclic AMP and ciliary neurotrophic factor on adult retinal ganglion cell survival and axonal regeneration. Mol. Cell Neurosci., 34: 88-98.

Dalton, P.D., Harvey, A.R., Oudega, M. and Plant, G.W. (2008) Tissue engineering of the nervous system, In: Tissue Engineering. C van Blitterswijk, P Thomsen, A Lindahl, J Hubbell, D Williams, R Cancellah, J de Bruijn, J Sohier (Eds.), Academic Press Series in Biomedical Engineering, pp. 611-647.

Fitzgerald, M., Bartlett, C.A., Evill, L., Rodger, J., Harvey A.R. and Dunlop, S.A. (2009) Secondary degeneration of the optic nerve following partial transection: the benefits of lomerizine. Exp. Neurol., 216: 219-230.

Harvey, A.R., Ehlert, E., de Wit, J., Drummond, E.S., Pollett, M.A., Ruitenberg, M.J., Plant, G.W., Verhaagen, J. and Levelt, C. (2009) Use of GFP to analyze morphology, connectivity, and function of cells in the central nervous system. In: Methods Mol. Biol., Viral Applications of Green Fluorescent Protein, R Hicks (Ed), 515: 63-95 (figure used as front cover for book).

Hellström, M., Pollett. M.A., Ruitenberg, M.J., Ehlert, E.M.E., Twisk, J., Verhaagen, J. and Harvey, A.R. (2009) Cellular tropism and transduction properties of 7 adeno-associated viral vector serotypes in adult retina after vitreal injection. Gene Ther., 16: 521-532.

Hodgetts, S.I., Plant, G.W. and Harvey, A.R. (2009) Spinal cord injury: experimental animal models and relation to human therapy. In: The Spinal Cord: A Christopher and Dana Reeve Foundation Text and Atlas. C Watson, G Paxinos, G Kayalioglu, C Heise (Eds) Elsevier, pp 223-251.

Lee, J-P., Tsai, D.J., Park, K.I., Harvey, A.R. and Snyder, E.Y. (2009) The dynamics of long-term transgene expression in engrafted neural stem cells. J Comp. Neurol., 515: 83-92.

Park, K.K., Hu, Y., Muhling, J., Pollett, M.A., Dallimore, E.J., Turnley, A.M., Cui, Q. and Harvey, A.R. (2009) Cytokine-induced SOCS expression is inhibited by cAMP analogue: impact on regeneration of injured retina. Mol. Cell Neurosci., 41: 313-324.

Vukovic, J., Ruitenberg, M.J., Roet, K., Fransen, E., Arulpragasam, A., Sasaki, T., Verhaagen, J., Harvey, A.R., Busfield, S. and Plant, G.W. (2009) The glycoprotein fibulin-3 regulates morphology and motility of olfactory ensheathing glia in vitro. Glia 57: 424-443.

Watson, C.R.R. and Harvey A.R. (2009) Brain projections to the spinal cord. In: The Spinal Cord: A Christopher and Dana Reeve Foundation Text and Atlas. C Watson, G Paxinos, G Kayalioglu, C Heise (Eds), Elsevier, pp 182-193.

Dallimore, E.J., Park, K.K., Pollett, M.A., Taylor, J.S. and Harvey, A.R. (2010) The life, death and regenerative ability of immature and mature rat retinal ganglion cells is influenced by their birthdate. Exp. Neurol., 225: 353-365.

Fitzgerald, M., Bartlett, C.A., Harvey, A.R. and Dunlop, S.A. (2010) Early events of secondary degeneration after partial optic nerve transection: an immunohistochemical study. J. Neurotrauma, 27: 439-452.

Fitzgerald, M., Bartlett, C.A., Payne, S. C., Rodger, J., Harvey, A.R. and Dunlop, S.A. (2010) Near infra-red light reduces oxidative stress and preserves function in CNS tissue vulnerable to secondary degeneration following partial traumatic injury. J Neurotrauma, 27: 2107–2119.


Wilks, T.A., Rodger, J. and Harvey, A.R. (2010) A role for ephrin-As in maintaining topographic organisation in register across interconnected central visual pathways. Eur. J. Neurosci., 31: 613-622.

Blomster, L., Vukovic, J., Hendrickx, D.A., Jung, S., Harvey, A.R., Filgueira, L. and Ruitenberg, M.J. (2011) CX3CR1 deficiency exacerbates neuronal loss and impairs early regenerative responses in the target-ablated olfactory epithelium. Mol. Cell Neurosci., 48: 236-245.

Clemons, T.D., Evans, C.W., Zdyrko, B., Luzinov, I., Fitzgerald, M., Dunlop, S.A., Harvey, A.R., Iyer, K.S. and Stubbs, K.A. (2011) Multifunctional nanoadditives for the thermodynamic and kinetic stabilization of enzymes. Nanoscale 3: 4085-4087.

Evans, C.W., Fitzgerald, M., Clemons, T.D., House, M.J., Padman, B.S., Shaw, J.A., Saunders, M., Harvey, A.R., Zdyrko, B., Luzinov, I.A., Silva, G.A., Dunlop, S.A. and Iyer, K.S. (2011) Multimodal analysis of PEI-mediated endocytosis of nanoparticles in neural cells. ACS Nano 5: 8640-8648.

Hellström, M. and Harvey, A.R. (2011) Retinal ganglion cell gene therapy and visual system repair. Curr Gene Ther., 11: 116-131.

Hellström, M., Mulling, J., Ehrlert, E., Verhaagen, J., Pollett, M.A., Hu, Y. and Harvey, A.R. (2011) Negative impact of rAAV2 mediated expression of SOCS3 on the regeneration of adult retinal ganglion cell axons. Mol. Cell Neurosci., 46: 507-515.

Plant, G.W., Harvey, A.R., Leaver, S.G. and Lee, S.V. (2011) Olfactory ensheathing glia: Repairing injury to the mammalian visual system. Exp. Neurol., 229: 99-108.

Harvey, A.R. (2012) Evolution, music and neurotherapy. In: Pragmatic Evolution: Applications of Evolutionary Theory (A Poiani, Ed), Cambridge University Press, Cambridge. pp 150-163.

Rodger, J., Drummond, E.S., Hellström, M., Robertson, D. and Harvey, A.R. (2012) Long-term gene therapy causes transgene-specific changes in the morphology of regenerating retinal ganglion cells. PLoS ONE, 7(2): e31061. doi:10.1371



Hellström, M., Pollett, M.A. and Harvey, A.R. (2011) Post-injury delivery of rAAV2-CNTF combined with short-term pharmacotherapy is neuroprotective and promotes extensive axonal regeneration after optic nerve trauma. J. Neurotrauma, 28: 2475-2483.

Future research
Continued studies on the use of gene therapy and transplantation in CNS repair. Additional ARC funded collaborative studies on nanotechnology are also in progress. Developmental neurobiology studies are underway, examining changes in neurons as they grow and send their axons into target regions in the brain.
Funding received
In 2012 Alan Harvey is funded by two NHMRC Project Grants and is a co-CI on two ARC Discovery Grants. He is also supported by the WA Neurotrauma Research Program.
Memberships
Member of
American Neuroscience Society
Australian Neuroscience Society
The International Neural Transplantation Council (1999- )
Now Chair of the International Programming Committee, Asia Pacific Symposia on Neural Regeneration
The International Scientific Committee, Spinal Cure Australia (2004- )
Board member of The Neurological Council of WA (2004- )
Current external positions
Alan Harvey is a member of: the International Neural Transplantation Council (1999- ); Chair of the International Programming Committee, Asia Pacific Symposia on Neural Regeneration; member of the International Scientific Committee, Spinal Cure Australia (2004- ); Board Member of the Neurological Council of WA (2004- ). He was a member of the WA Reproducrtive Technology Council for 10 years, 1996-2006.
Current projects
Continued studies on the use of gene therapy and transplantation in CNS repair. Additional ARC funded collaborative studies on nanotechnology are also in progress. Developmental neurobiology studies are underway, examining changes in neurons as they grow and send their axons into target regions in the brain.
Research profile
Research profile and publications
 

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Monday, 1 October, 2012 4:15 PM

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