The University of Western Australia

Professor Luis Filgueira

Professor
School of Anatomy, Physiology and Human Biology

Contact details

Address

School of Anatomy, Physiology and Human Biology
The University of Western Australia (M309)
35 Stirling Highway
CRAWLEY WA 6009
Australia

Phone

6488 3907

Fax

6488 1051

Email

luis.filgueira@uwa.edu.au

Personal homepage

http://school.anhb.uwa.edu.au/personalpages/filgueira/default_files/slide0001.htm

Qualifications

MD Basel

Biography

Professor Luis Filgueira graduated in 1985 (doctorate in 1987) in human medicine at the University of Basel, Switzerland. He did several years of internship as clinical and research fellow at different hospitals in Switzerland, to be trained as a surgeon. Because of his love to basic science and teaching, he moved into teaching and research in 1994, to become a senior teaching and research fellow in anatomy at the University of Zurich. After Habilitation in the area of Immunology in 2001 at the University of Zurich, he moved to Australia and accepted the present appointment.
His research interests are in cellular immunology and bone research, using a variety of morphological, cellular and molecular methods and addressing basic, but clinically relevant questions. At UWA, he has done substantial research in the area of metals in biology, focussing on side effects of orthopaedic implants on immune functions.

Key research

Dendritic Cell Development and Function

Cancer and Immunity

Osteoclast Development and Function

Osteoblast Development and Function

Bone and Immunity

Biological Electron Microscopy

Metal Allergy

Breastmilk Stem Cells

Tertiary Education

Publications

Publications 2011
Toai TC, Thao HD, Gargiulo C, Thao NP, Tuan HM, Tung NT, Filgueira L, Strong DM.
In Vitro Culture of Keratinocytes from Human Umbilical Cord Blood Mesenchumal Stem Cells: The Saigonese Culture.
CELL TISSUE BANKING 2011, 12, 125-133.

Wedlock LE, Kilburn MR, Cliff JB, Filgueira L, Saunders M, Berners-Price SJ. Nano-scale secondary ionisation mass spectrometry (NanoSIMS) imaging shows the subcellular distribution of gold in situ, in the cytoplasm and nuclei of tumour cells after treatment with an antitumour gold(I) compound.
METALLOMICS 2011, 3, 917.

Blomster LV, Vukovic J, Hendricks DAE, Jung S, Harvey AR, Filgueira L, Ruitenberg MJ.
CX3CR1 deficiency exacerbates neuronal loss and impairs early regenerative.
MOLLECULAR AND CELLULAR NEUROSCIENCE 2011, 48, 236-245.

Tran CT, Garciulo C, Thao HD, Tuan HM, Filgueira L, Strong DM.
Culture and differentiation of osteoblasts on coral scaffold from human bone marrow mesenchymal stem cells.
CELL AND TISSUE BANKING 2011, 14, 247-261.

Chan E, Cadosch D, Gautschi OP, Sprengel K, Filgueira L.
Influence of metal ions on human lymphocytes and the generation of titanium-specific T-lymphocytes
JOURNAL OF APPLIED BIOMATERIALS & BIOMECHANICS 2011, 9, 137-143.

Publications 2010
Cadosch D, Al-Mushaiqri MS, Gautschi OP, Meagher J, Simmen HP, Filgueira L.
Biocorrosion and uptake of titanium by human osteoclasts.
J Biomed Mater Res A. 2010 Dec 15;95(4):1004-10.

Cadosch D, Thyer M, Gautschi OP, Lochnit G, Frey SP, Zellweger R, Filgueira L, Skirving AP.
Functional and proteomic analysis of serum and cerebrospinal fluid derived from patients with traumatic brain injury: a pilot study.
ANZ J Surg. 2010 Jul-Aug;80(7-8):542-7.

Cadosch D, Schlett CL, Gautschi OP, Frei HC, Filgueira L.
[Metal ions: important co-players in aseptic loosening]
Z Orthop Unfall. 2010 Aug;148(4):393-7.

Cadosch D, Toffoli AM, Gautschi OP, Frey SP, Zellweger R, Skirving AP, Filgueira L.
Serum after traumatic brain injury increases proliferation and supports expression of osteoblast markers in muscle cells.
J Bone Joint Surg Am. 2010 Mar;92(3):645-53.

Cadosch D, Sutanto M, Chan E, Mhawi A, Gautschi OP, von Katterfeld B, Simmen HP, Filgueira L.
Titanium uptake, induction of RANK-L expression, and enhanced proliferation of human T-lymphocytes.
J Orthop Res. 2010 Mar;28(3):341-7.

Cadosch D, Al-Mushaiqri MS, Gautschi OP, Chan E, Jung FJ, Skirving AP, Filgueira L.
Immune response deviation and enhanced expression of chemokine receptor CCR4 in TBI patients due to unknown serum factors.
Injury. 2010 Jun;41(6):e4-9. Epub 2009 Sep 24.

Cadosch D, Gautschi OP, Chan E, Simmen HP, Filgueira L.
Titanium induced production of chemokines CCL17/TARC and CCL22/MDC in human osteoclasts and osteoblasts.
J Biomed Mater Res A. 2010 Feb;92(2):475-83.

Publications 2007-2009
Cadosch D, Chan E, Gautschi OP, Meagher J, Zellweger R, Filgueira L
Titanium IV Ions Induced Human Osteoclast Differentiation and Enhanced Bone Resorption in vitro
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH 91A:29-36 2009

Cadosch D, Chan E, Gautschi OP, Simen HP, Filgueira L
Bio-corrosion of stainless steel by osteoclasts - In Vitro evidence
JOURNAL OF ORTHOPAEDIC RESEARCH 27:841-846 2009

Cadosch D, Meagher J, Gautschi OP, Filgueira L
Uptake and intracellular distribution of various metal ions in human monocyte-derived dendritic cells detected Newport Green DCF diacetate ester.
JOURNAL OF NEUROSCIENCE METHODS 178:182-187 2009

Cadosch D, Sutanto M, Chan M, Mhawi A, Gautschi OP, von Katterfeld B, Filgueira L
Titanium Uptake, Induction of RANK-L Expression and Enhanced Proliferation of Human T-Lymphocytes.
JOURNAL OF ORTHOPAEDIC RESEARCH, accepted for publication August 2009

Cadosch D, Chan E, Gautschi OP, Filgueira L
“Metal is not inert”. Role of metal ions released by biocorrosion in aseptic loosening. – Current concepts-
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH: Part A, accepted for publication August 2009

Cadosch D, Chan E, Gautschi O, Simen HP, Filgueira L
Titanium induced production of chemokine CCL17/TARC and CCL22/MDC in human osteoclasts and osteoblasts
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH: Part A, accepted for publication November 2008

Chan E, Mhawi A, Clode P, Saunders M, Filgueira L
Effects of Ti(IV) ions on human monocyte-derived dendritic cells
METALLOMICS 1: 166-174 2009

Chan E, Filgueira L
Effect of vanadium on human dendritic cells
TOXICOLOGICAL AND ENVIRONMENTAL CHEMISTRY, accepted March 2009

Gautschi OP, Cadosch D, Frey SP, Joesbury KA, Zellweger R, Filgueira L
Apoptosis induction and reduced proliferation in human osteoblasts by rhBMP-2, -4 and -7
JOURNAL OF MUSCULOSKELETAL NEURONAL INTERACTION 9:53-60 2009

Gautschi OP, Cadosch D, Frey SP, Skirving AP, Filgueira L, Zellweger R
Serum-mediated osteogenic effect in traumatic brain injured patients
ANZ JOURNAL OF SURGERY 79:449-455 2009

Cadosch D, Thyer M, Gautschi OP, Lochnit G, Frey SP, Skirving AP, Zellweger R, Filgueira L
Functional and proteomic analysis of Serum and CSF derived from patients with TBI
ANZ JOURNAL OF SURGERY; accepted for publication November 2008.

Cadosch D, Al-Mushaiqri MS, Gautschi OP, Chan E, Skirving AP, Filgueira L
Immune Response Deviation and Enhanced Expression of Chemokine Receptor CCR4 in TBI Patients due to Unknown Serum Factors
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED, accepted for publication September 2009

Cadosch D, Bauer S, Gautschi OP, Filgueira L, Zellweger R
Surgical arthrolysis in patients with with high-grade heteroptopic ossification after hip joint endoprothesis.
UNFALLCHIRURG 111: 535-538 2008

Gautschi OP, Cadosch D, Bauer S, Filgueira L, Zellweger R
Heterotopic ossification - from the aetiology to the current managment.
UNFALLCHIRURG 111(7): 523-533 2008

Ruitenber MJ, Vukovic J, Blomster L, Hall JE, Jung S, Filgueira L, McMenamin PG, Plant GW
CX3CL1/Fractalkine regulates branching and migration of monocyte-derived cells in the mouse olfactory epithelium.
JOURNAL OF NEUROIMMUNOLOGY 205:80-85 2008

Toffoli AM, Gautschi OP, Frey SP, Filgueira L, Zellweger R
From brain to bone: Evidence for the release of osteogenic humoral factors after traumatic brain injury
BRAIN INJURY 22: 511-518 2008

Cadosch D, Thyer M, Frey S, Lochnit G, Filgueira L, Zellweger R
Functional and proteomic analysis of cerebrospinal fluid derived from patients with and without traumatic brain injury
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS 205:S45 2007

Foo C, Frey S, Yang HH, Zellweger R, Filgueira L
Downregulation of b-catenin and transdifferentiation of human osteoblasts to adipocytes under estrogen deficiency
GYNECOLOGICAL ENDOCRINOLOGY 23: 535–540 2007

Gautschi OP, Toffoli AM, Joesbury KA, Skirving AP, Filgueira L, Zellweger R
Osteoinductive effect of cerebrospinal fluid from brain-injured patients
JOURNAL OF NEUROTRAUMA 24 (1): 154-162 2007


Selected publications before 2006

von Garnier C, Filgueira L, Wikstrom M, Smith M, Thomas JA, Strickland DH, Holt PG, Stumbles PA
Anatomical location determines the distribution and function of dendritic cells and other APCs in the respiratory tract
JOURNAL OF IMMUNOLOGY 175: 1609-1618 1 2005

Meagher J, Zellweger R, Filgueira L
Functional dissociation of the basolateral transcytotic compartment from the apical phago-lysosomal compartment in human osteoclasts
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY 53: 665-670 2005

Eppler E, Walch M, Latinovic-Golic S, Dumrese C, Filgueira L, Groscurth P
Human dendritic cells process and present Listeria antigens for in vitro priming of autologous CD4+T lymphocytes
HISTOCHEMISTRY AND CELL BIOLOGY 123: 169-178 2005

Cavanagh LL, Boyce A, Smith L, Padmanabha J, Filgueira L, Pietschmann P, Thomas R
Rheumatoid arthritis synovium contains plasmacytoid dendritic cells
ARTHRITIS RESEARCH & THERAPY 7: R230-R240 2005

Yan MY, Peng J, Jabbar IA, Liu XS, Filgueira L, Frazer IH, Thomas R
Activation of dendritic cells by human papillomavirus-like particles through TLR4 and NF-kappa B-mediated signalling, moderated by TGF-beta
IMMUNOLOGY AND CELL BIOLOGY 83: 83-91 2005

Nunez R, Garay N, Bruno A, Villafane C, Bruno E, Filgueira L
Functional and structural characterization of two populations of human monocyte-derived dendritic cells
EXPERIMENTAL AND MOLECULAR PATHOLOGY 77: 104-115 2004

Yan MY, Peng J, Jabbar IA, Liu XS, Filgueira L, Frazer IH, Thomas R
Despite differences between dendritic cells and Langerhans cells in the mechanism of papillomavirus-like particle antigen uptake, both cells cross-prime T cells
VIROLOGY 324: 297-310 1 2004

Filgueira L
Fluorescence-based staining for tartrate-resistant acidic phosphatase (TRAP) in osteoclasts combined with other fluorescent dyes and protocols
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY 52: 411-414 2004

Neumann K, Eppler E, Filgueira L, Groscurth P, Gasal E, Schaffner A, Schoedon G, Schneemann M
Listeria species escape from the phagosomes of interleukin-4-deactivated human macrophages independent of listeriolysin
IMMUNOLOGY AND CELL BIOLOGY 81: 431-439 2003

Matter-Reissmann UB, Forte P, Schneider MKJ, Filgueira L, Groscurth P, Seebach JD
Xenogeneic human NK cytotoxicity against porcine endothelial cells is perforin/granzyme B dependent and not inhibited by Bcl-2 overexpression
XENOTRANSPLANTATION 9: 325-337 2002

Eppler E, Horig H, Kaufman HL, Groscurth P, Filgueira L
Carcinoembryonic antigen (CEA) presentation and specific T cell-priming by human dendritic cells transfected with CEA-mRNA
EUROPEAN JOURNAL OF CANCER 38: 184-193 2002

Wu SJL, Grouard-Vogel G, Sun W, Mascola JR, Brachtel E, Putvatana R, Louder MK, Filgueira L, Marovich MA, Wong HK, Blauvelt A, Murphy GS, Robb ML, Innes BL, Birx DL, Hayes CG, Frankel SS
Human skin Langerhans cells are targets of dengue virus infection
NATURE MEDICINE 6: 816-820 2000
Times Cited: 192

Nestle FO, Filgueira L, Nickoloff BJ, Burg G
Human dermal dendritic cells process and present soluble protein antigens
JOURNAL OF INVESTIGATIVE DERMATOLOGY 110: 762-766 1998
Times Cited: 45

Grouard G, Rissoan MC, Filgueira L, Durand I, Banchereau J, Liu YJ
The enigmatic plasmacytoid T cells develop into dendritic cells with interleukin (IL)-3 and CD40-ligand
JOURNAL OF EXPERIMENTAL MEDICINE 185: 1101-1111 1997
Times Cited: 599

Grouard G, Durand I, Filgueira L, Banchereau J, Liu YJ
Dendritic cells capable of stimulating T cells in germinal centres
NATURE 384 (6607): 364-367 1996
Times Cited: 199

Filgueira L, Nestle FO, Rittig M, Joller HI, Groscurth P
Human dendritic cells phagocytose and process Borrelia burgdorferi
JOURNAL OF IMMUNOLOGY 157: 2998-3005 1996
Times Cited: 96

Funding received

ITI International Team for Implantology Grant 741_2011
Title:Biological effects of implant derived vanadium on human osteoclasts
2011/2012: SFR 50,000
Chief Investigator

AO Research Foundation, Switzerland 05-Z34
Title: Immune reactivity against orthopaedic metal implants
November 2005 – October 2007: SFR 120,000 (about AU$ 120,000)
Chief investigator together with Dr. Rene Zellweger

NIH/NIGMS 1RO1 GM072726-A1:
Title: Metal processing by dendritic cells and osteoclasts
July 2005 –June 2007: US$ 270,000 (about AU$ 340,000)
Chief investigator

AO Research, Switzerland 03-4F
Title: Immune function of human osteoclasts
July 2003 – June 2005: SFR 100,000 ( about AU$ 100,000)
Chief investigator

Swiss National Science Foundation 31-61337
Title: Antigen-presentation of Borrelia-derived lipid antigens.
2001-2002: SFR 96,000 (about AU$ 100,000)
Chief investigator

Swiss National Science Foundation 31-043186
Title: Lipid antigens from Borrelia burgdorferi: characterization and influence on dendritic cells and T cells
1996-2000: SFR 197,036 (about AU$ 200,000)
Chief investigator

Languages

German, Spanish, English

Teaching

Anatomy
Histology
Cell Biology
Immunology

Current projects

1. Lead (Pb) immune and neurotoxicity
2. Osteoclastic biocorrosion of medical metal implants
3. The role of inflammatory factors on peripheral arterial disease
4. Biology of breastmilk stem cells

Research profile

Research profile and publications