The University of Western Australia

Burns, D.M., Abraham, L.J., Beacham, I.R. Characterisation of the ush gene of Escherichia coli and its gene products. Gene 25: pp 343-353 (1983)

Abraham, L.J., Rood, J.I. Molecular analysis of transferable resistance plasmids from Clostridium perfringens. J. Bacteriol. 161: pp 636-640 (1985).

Abraham, L.J., Rood, J.I. Cloning and analysis of the Clostridium perfringens tetracycline resistance plasmid, pCW3. Plasmid 13: pp 155-162 (1985).

Abraham, L.J., Wales, A.J., Rood, J.I. Worldwide distribution of the con-jugative Clostridium perfringens tetracycline resistance plasmid, pCW3. Plasmid 14: pp 37-46 (1985)

Abraham, L.J., Rood, J.I. Identification of Tn4451 and Tn4452: Chloramphenicol resistance transposons from Clostridium perfringens. J Bacteriol. 169: pp 1579-1584 (1987)

Abraham, L.J., Berryman, D.I., Rood, J.I. Hybridisation analysis of the Class P tetracycline resistance determinant from the Clostridium perfringens R-plasmid, pCW3. Plasmid 19: pp 113-120 (1988).

Abraham, L.J., Rood, J.I. The Clostridium perfringens Chloramphenicol resistance transposon Tn4451 excises precisely in Escherichia coli. Plasmid 19: pp 164-168 (1988)

Fey, G.H., Hattori, M., Northmann, W., Abraham, L.J. , Baumann, M. , Braciak, T.A., Fletcher, R.G., Gauldie, J., Lee, F., Reymond, M.F. Regulation of rat liver acute phase genes by Interleukin 6 and production of hepatoctye stimulating factors by rat hepatoma cells. Annals N.Y. Acad Sci. 557: pp 317-329 (1989)

Hattori, M., Abraham, L.J., Fey, G.H. Identification of an Interleukin 6 response element in the rat alpha-2-macroglobulin gene. Annals N.Y.Acad. Sci. 557: pp 499-501 (1989)

Abraham, L.J., Bradshaw, A.D., Fletcher, R.G., Fey, G.H. Interleukin 6 is a negative regulator of the liver acute phase alpha-1-inhibitor III gene. Molecular Biol. Medicine. 7: pp 261-271 (1990)

Abraham, L.J., Bradshaw, A.D., Shiels, B.R., Northeman, W., Hudson, G., Fey, G.H. Hepatic transcription of the acute phase alpha-1-inhibitor III gene is controlled by a novel combination of cis-acting regulatory elements. Molec.Cellular Biol. 10: pp 3483-3491 (1990)

Hattori, M., Abraham, L.J., Northeman, W., Fey, G.H. The Acute Phase Reaction induces a specific complex between Hepatic Nuclear Proteins and the Interleukin 6 Response Element of the Rat alpha 2- macroglobulin, Gene. Proc. Natl. Acad. Sci. USA. 87: pp 2364-2368 (1990)

Northeman, W., Hattori, M., Baffet, G., Braciak, T.A., Fletcher, R.G., Abraham, L.J.,Gauldie, J., Bauman, M., Fey, G.H. Production of interleukin 6 by Hepatoma Cells. Molecular Biol. Medicine 7: pp 273-285 (1990)

Abraham, L.J., Bradshaw, A.D., Northeman, W., Fey, G.H. Identification of a Glucocorticoid Response Element Contributing to the Constitutive Expression of the Rat Liver alpha-1-inhibitor III gene. J. Biol. Chem. 266: pp 18268-18275 (1991)

Abraham, L.J., Chin Du, D., Zahedi, K., Dawkins, R.L., and A.S. Whitehead Haplotypic polymorphism of the TNFB gene. Immunogenetics 33: pp 50-53 (1991)

Wu, X., Zhang, W.J., Witt, C.S., Abraham, L.J., Christiansen, F.T., Dawkins, R.L. Haplospecific polymorphism between HLA B and TNF. Human Immunol. 33: pp 89-97 (1992)

Leelayuwat, C., Abraham, L.J., Tabarias, H., Christiansen, F.T., Dawkins, R.L. Genomic organization of a polymorphic duplicated region centromeric of HLA B. Immunogenetics 36: pp 208-212 (1992).

Abraham, L.J., Leelayuwat, C., Grimsley, G., Degli-Esposti, M.A., Mann, A., Zhang, W.J., Christiansen, F.T., Dawkins, R.L. Sequence Differences between HLA B and TNF distinguish different MHC Ancestral Haplotypes. Tissue Antigens 39: pp 117-121 (1992)

Abraham, L.J., Grimsley, G., Zhang, W.J., Degli-Esposti, M.A., Dawkins, R.L. Polymorphism in the Human B144 Gene in Different MHC Haplotypes. Eur J Immunogenetics 19: pp 165-168 (1992)

Degli-Esposti, M.A., Abraham, L.J., McCann, V., Spies, T., Christiansen, F.T. Dawkins, R.L. Ancestral haplotypes reveal the role of the Central MHC in the Immunogenetics of IDDM. Immunogenetics 36: pp 345-356 (1992)

Degli-Esposti, M.A., Leaver, A.L., Christiansen, F.T., Witt, C.S., Abraham, L.J., Dawkins, R.L. Ancestral Haplotypes : conserved population MHC haplotypes. Human Immunology 34: pp 242-252 (1992)

Zhang, W.J., Christiansen, F.T., Wu, X., Abraham, L.J., Giphart, M., and Dawkins, R.L. Organization and evolution of C4 and CYP21 Genes in Primates : Importance of genomic segments. Immunogenetics 37: pp 170-176 (1993).

Marshall, B., Leelayuwat, C., Degli-Esposti, M.A., Pinelli, M., Abraham, L.J., Dawkins, R.L. New MHC Genes. Human Immunol. 38: pp 24-29 (1993)

Mann, A.J., Abraham, L.J., Cameron, P.U., Robinson, W., Giphart, M.J., Dawkins, R.L. The Caprine MHC contains DYA Genes. Immunogenetics 37: pp 292-295 (1993)

Abraham, L.J., French, M.A.H., Dawkins, R.L. Haplospecific polymorphism of major histocompatibility complex genes affects the activity of Tumour Necrosis Factor - alpha. Clin. Exp. Immunol. 92: pp 14-18 (1993)

Abraham, L.J., Marley, J.V. Nedospasov, S.A., Cambon-Thomsen, A., Crouau-Roy, B., Dawkins, R.L., Giphart, M. Microsatellite, RFLP and SSO typing of the TNF region. Human Immunol. 38: pp 17-23 (1993)

Christiansen, F.T., Witt, C.S., Ciccone, E., Townend, D., Pende, D., Viale, D., Abraham, L.J., Dawkins, R.L., Moretta, L. Human Alloreactivity and its association with the Major Histocompatibility Complex: Ancestral Haplotypes encode Particular NK-defined Haplotypes. J Exp. Med. 178: pp 1033-1039 (1993)

Marshall, B., Tay, G., Marley, J., Abraham, L.J., Dawkins, R.L. Analysis of MHC Genome Structure and Gene Content between HLA-B and TNF using Yeast Artificial Chromosomes. Genomics 17: pp 435-441 (1993)

Leelayuwat, C., Zhang, W.J., Abraham, L.J., Townend, D.C., Dawkins, R.L. Differences in the Central MHC between Man and Chimpanzee: Implications for Autoimmunity and Aquired Immunodeficiency Disease Syndrome. Human Immunol. 38: pp 30-41 (1993).

Abraham, L.J., Grimsley, G., Leelayuwat, C., Townend, D., Pinelli, M., Christiansen, F.T. Dawkins, R.L. A region centromeric of the MHC Class I region is as highly polymorphic as HLA-B: Implications for recombination. Human Immunol. 38: pp 75-82 (1993)

Marshall, B., Leelayuwat, C., Abraham, L.J., Pinelli, M., Dawkins, R.L. Large Transcripts and Sequence from a polymorphic MHC region of 170 kb implicated in Susceptibility to Autoimmune Disease. Immunogenetics 39: pp 15-20 (1994)

Leelayuwat, C., Townend, D.C., Degli-Esposti, M.A., Abraham, L.J., and Dawkins, R.L. New polymorphic and multicopy MHC gene Family related to Nonmammalian Class I. Immunogenetics 40: pp 339-351 (1994)

Leelayuwat, C., Degli-Esposti, MA, Taylor, E., Abraham, LJ, Dawkins, RL. PCR SSCP reveals Haplotype related polymorphism of PERB1 : A new marker for MHC b Block Typing. Eur J Immunogenet. 21: pp 431-446 (1994)

Leelayuwat, C., Abraham, L.J., Pinelli, M., Townend, D.C., Wilks, A.F., Dawkins, R.L. The Primate Mhc contains sequences related to the Fibroblast Growth Factor Receptor Gene Family. Tissue Antigens 48: pp 59-64 (1996)

Ulgiati, D., Townend, D.C., Christiansen, F.T., Dawkins, R.L., Abraham, L.J. Complete Sequence of the Complement C4 Gene from the HLA- A1, B8, C4AQ0, C4B1, DR3 Haplotype. Immunogenetics 43: pp 250-252 (1996).

Ulgiati, D., Grimsley, G., Leelayuwat, C., Abraham, L.J. Analysis of the Major Histocompatibility Complex Microsatellite CL-1 in different Human Haplotypes. Eur. J. Immungenet. 23: pp 205-209 (1996)

Kroeger, K.M., Abraham, L.J. Identification of an AP-2 Element in the -323 to -285 region of the TNF-alpha Gene. Biochem. Mol. Biol. Int. 40: pp 43-51 (1996)

Ulgiati, D., Abraham, L.J. Comparative analysis of the Disease associated Complement C4 gene from the HLA - A1, B8, DR3 Haplotype. Exp.Clin. Immunogenet. 13:pp 43-54 (1996)

Ulgiati, D., Abraham, L.J. Extensive Conservation of Upstream C4 promoter Sequences: A Comparison between C4A and C4B. Tissue Antigens 48: pp 600-603 (1996)

Abraham, LJ,Whelan, J Perspectives from Conducting a Molecular Biology Workshop in Malaysia. Biochem. Education 24: pp 212-213 (1996)

Laham, N., van Dunne, F., Abraham, LJ., Bendtzen, K., Brennecke, S.P., Rice, G.E. Tumour Necrosis Factor-beta in Human Pregnancy and Labour. J. Reprod. Immunol. 33: pp 53-69 (1997)

Kroeger, K.M., Carville, K.S. and Abraham, L.J. The -308 Tumour Necrosis Factor-alpha Promoter Polymorphism effects Transcription. Molec. Immunol. 34: pp 391-399 (1997)

Croager, E.J., Abraham, L.J. Characterisation of the Human CD30 Ligand Gene Structure. Biochim. Biophys. Acta 1353: pp 231-235 (1997)

Kroeger, K.M.,Abraham, L.J. Magnetic Bead Purification of Specific Transcription Factors using Mutant Competitor Oligonucleotides. Anal. Biochem. 250: pp 127-129 (1997)

Joyce, D.A., Steer, J.H., Abraham, L.J. Glucocorticoid Modulation of Human Monocyte / Macrophage Function: Control of TNF-alpha Secretion. Inflamm. Res. 46: pp 447-451 (1997)

Ulgiati, D, Townend, D.C., Christiansen, F.T., Abraham, L.J. A New Australian Aboriginal Complotype characterised by Three C4 Genes. Exp.Clin. Immunogenet. 15 (3): 134-143 (1998)

Croager, E.J. , Muir, T.M., Abraham, L.J. Analysis of the Human and Mouse Promoter Region of the non-Hodgkin's Lymphoma - associated CD30 Gene. J. Interfer.Cytokine Res 8: pp 915-920 (1998)

Kok, C.C, Croager, E.J., Witt, C.S., Kiers, L., Mastaglia, F.L., Abraham, L. J., Garlepp, M. J. Mapping of the Inclusion Body Myositis Susceptibility Gene in the Human Major Histocompatibility Complex. Immunogenetics 49: pp 508-516 (1999)

van Maanen, M-H., Fournier, P.A., Palmer, T.N., Abraham, L.J. Characterization of Mouse Glycogenin-1 cDNA and Promoter region. Biochim. Biophys. Acta 1447: pp 284-290 (1999).

Abraham, L.J., Kroeger, K.M. Impact of the -308 Tumor Necrosis Factor (TNF) Promoter Polymorphism on the Transcriptional Regulation of the Tumor Necrosis Factor (TNF) Gene: Relevance to Disease. J. Leuk. Biol. 66: pp 562-566 (1999)

van Maanen, M-H., Fournier, P.A., Palmer, T.N., Abraham, L.J. Characterisation of the Human Glycogenin-1 Gene: Identification of a Muscle-specific regulatory Domain. Gene (1999).

Ulgiati, D. , Subrata, L.S., Abraham, L.J. The Role of Sp Family Members, Basic Kruppel-Like Factor and E box Factors in the Basal and Interferon-g regulated Expression of the Human Complement C4 Promoter. J. Immunol. 164: pp 300-307 (2000).

Kroeger, K.M., Steer, J.H., Joyce, D.A., Abraham, L.J. Effects of Stimulus and Cell Type on the Expression of the -308 TNF-a Promoter Polymorphism. Cytokine 12: pp 110-119 (2000)

Croager, E.J., Gout, A., Abraham, L.J. Involvement of Sp1 and Microsatellite Repressor Sequences in the Transcriptional Control of the Human CD30 Gene. Am. J Pathol. 156: pp 1723-1731 (2000)

Steer, J.H., Kroeger, K.M., Abraham, L.J., Joyce, D.A. Glucocorticoids suppress Tumor Necrosis Factor-a Expression by Human Monocytic THP-1 Cells by Suppressing Transactivation through Adjacent NF-kB and c-Jun-Activating Transcription Factor-2 binding Sites in the Promoter. J. Biol. Chem. 275: pp 18432-18440 (2000)

Knight, B., Yeoh, G.C.T., Husk, K.L., Ly, T., Abraham, L.J., Yu, C., Rhim, J.A., and Fausto, N. Impaired Preneoplastic Changes and Tumor formation in TNF Receptor Type I Knockout Mice. J Exp. Med. 192: 1809-1818 (2001)

Voon, D.C. Subrata, L.S., and Abraham, L.J. Regulation of Lymphotoxin-b byTNF, PMA and ionomycin in Jurkat T cells. J. Interferon Cytokine Res. 21: pp 921-930 (2001)

Woo, A., Dods, J., Susanto, E., Ulgiati, D., and Abraham, L.J.A Proteomics Approach to the Identification of DNA Binding Activities observed in the Electrophoretic Mobility Shift Assay. Mol. Cell. Proteomics 1: pp 472-478 (2002)

Price, P., Morahan G., Huang D., Stone E., Cheong K.Y.M., Castley, A., Rodgers, M., McIntyre, M.Q., Abraham, L.J., and French, M.A.Polymorphisms in cytokine genes define subpopulations of HIV-1 patients who experienced immune restoration diseases.AIDS 16 : pp 2043-2047 (2002)

Goldie-Cregan, L.C., Croager, E.J., and Abraham, L.J.Characterisation of the Murine CD30 Ligand (CD153) Gene: Gene Structure and Expression. Tissue Antigens 60: pp 139-146 (2002)

Lowes, K.N., Croager, E.J., Olynyk, J.K., Abraham, L.J., and Yeoh , G.C.T. Oval cell-mediated liver regeneration:the role of cytokines and growth factors J. Gastroent. & Hepatol. 18: pp 4-12 (2003)

McIntyre, M.Q., Price, P., Franchina, M., French, M.A., and Abraham, L.J. Distribution of Human CD30 Gene Promoter Microsatellite Alleles in Healthy and HIV-1 infected Populations. Eur. J. Immunogenet. 30: pp 125-128 (2003)

Lowes, K.N., Croager, E.J., Abraham, L.J., Olynyk, J.K., and Yeoh, G.C.T. Lymphotoxin-b Expression in Human Chronic Liver Disease. Gut 52: pp 1327-1332 (2003).

Watanabe, M., Ogawa, Y., Ito, K., Higashihara, M., Kadin, M.E., Abraham, L.J., Watanabe, T., and Horie, R. AP-1 mediated relief of repressive activity of the CD30 microsatellite in Hodgkin and Reed-Sternberg cells. Am J Pathol 163: pp 633-641 (2003)

Maier, H., Ostraat, R., Parenti, S., Abraham, LJ, Garvie, C., and Hagman, J. Requirements for selective Recruitment of Ets proteins and Activation of mb-1/Ig-a Gene Transcription by Pax-5 (BSAP). Nucl. Acids Res. 31: pp 5483-5489 (2003)

Voon, D.C., Subrata, L.S., Karimi, M., Ulgiati, D., and Abraham, L.J.TNF-a and Phorbol Esters induce Lymphotoxin-b Expression through distinct Pathways involving ETS and NFkB family Members. J. Immunol. 172: pp 4332–4341 (2004)

Subrata, L.S., Lowes, K.N., Olynyk, J.K. , Yeoh, G.C.T., Quail, E.A. and Abraham, L.J. Hepatic Expression of the Tumour Necrosis Factor family member Lymphotoxin-b is regulated by IL-6 and IL-1b: Transcriptional Control Mechanisms in Oval Cells and Hepatoma Cell Lines. Liver Int. 25: pp 633-646 (2005)

Akhurst, B., Matthews, V., Husk, K., Smythe, M., Abraham, L.J., and Yeoh, G.C.T.Differential Lymphotoxin b and Interferon Gamma signalling during mouse liver regeneration induced by chronic and acute injury. Hepatology 41: pp 327-335 (2005)

Franchina, M., Kadin, M.E., Abraham, L.J. Polymorphism of the CD30 promoter microsatellite repressive element is associated with development of primary cutaneous lymphoproliferative disorders. Cancer Epidem., Biomarkers & Chemoprev. 14: pp 1322-1325 (2005)

Knight, B., Matthews, V,B., Akhurst, B., Croager, E.J., Klinken, E., Abraham, L.J., Olynyk, J.K., Yeoh, G.C.Liver Inflammation and Cytokine production, but not Acute Phase protein synthesis, accompany the Adult Liver Progenitor (Oval) cell response to Chronic Liver Injury. Immunol & Cell Biol. 83: pp 364-374 (2005)

Watanabe, M., Sasaki, M., Itoh,K., Higashihara,M., Umezawa,K., Kadin,M.E., Abraham,L.J., Watanabe,T and Hori,R. JunB induced by constitutive CD30–ERK1/2 MAPK signaling activates the CD30 promoter in anaplastic large cell lymphoma and Reed-Sternberg cells of Hodgkin lymphoma. Cancer Res. 65: pp 7628-7634 (2005)

Franchina, M., Karimi, M., Ho, D., and Abraham, L.J.Effects of CD30 Receptor Density on Intracellular signalling : Insights into Anaplastic Large Cell Lymphoma Treatment. Proc. Int. Cytokine Soc. 2006: pp 55-59 (2006)

Karimi, M., Goldie, L.C., Ulgiati, D., Abraham, L.J. Integration Site-specific Transcriptional Reporter Gene Analysis using Flp Recombinase Targeted Cell Lines. Biotechniques 42: pp 217-224 (2007)

Wu, H., Boackle, SA., Hanvivadhanakul, P., Ulgiati, D., Grossman, J.M., Youngho, L., Shen, N., Abraham, L.J., Mercer, T.R., Park, E., Hebert, L.A., Rovin, B.H., Birmingham, D.J., Chang, D.M., Chen, C.J., McCurdy, D., Badsha, H.M., Thong, B.Y.H., Chng, H.H., Arnett, F.C., Wallace, D.J., Yu, C.Y., Hahn, B.H., Cantor, R.M., Tsao, B.P. Association of a common complement receptor 2 haplotype with increased risk of systemic lupus erythematosus. Proc. Natl. Acad. Sci. USA. 104: pp 3961-3966 (2007)

Knight, B., Akhurst, B., Matthews, V.B., Ruddell, R.G., Ramm, G.A., Abraham, L.J., Olynyk, J.K., and Yeoh, G.C. Attenuated liver progenitor (oval) cell and fibrogenic responses to the choline deficient, ethionine supplemented diet in the BALB/c inbred strain of mice. J. Hepatology 46: pp 134-141 (2007)

Stewart, S.G., Spagnolo, D., Polomska, M.E., Sin, M., Karimi, M., Abraham, L.J. Synthesis and TNF inhibitory properties of new thalidomide analogues derived via Heck cross coupling. Bioorg Med Chem Lett 17: pp 5819-5824 (2007).

Göring, H.H.H., Curran, J.E., Johnson, M.P., Dyer, T.D., Cole, S.A., Jowett, J.B.M., Abraham, L.J., Rainwater, D.L., Comuzzie, A.G., Mahaney, M.C., Almasy, L., MacCluer, J.W., Kissebah, A.H., Collier, G.R., Moses, E.K., Blangero, J.Discovery of expression QTLs using large-scale transcriptional profiling in human lymphocytes. Nature Genetics 39: pp 1208-1216 (2007)

Franchina, M., Woo, A., Dods, J., Karimi, M., Ho, D., Watanabe,T., Spagnolo, D.V., and Abraham, L.J.The CD30 Gene Promoter Microsatellite binds Transcription Factor Yin Yang 1 (YY1) and shows Genetic Instability in Anaplastic Large Cell Lymphoma. J Pathol. 214: pp 65-74 (2008)

Cruickshank, M., Fenwick, E., Abraham, L.J., Ulgiati, D.Quantitative differences in chromatin accessibility across regulatory regions can be directly compared in distinct cell-types. Biochem. Biophys. Res. Com. 367: pp 349-355 (2008)

Moses, E.K., Johnson, M.P., Tømmerdal, L., Forsmo, S., Curran, J.E., Abraham, L.J., Brennecke, S.P., Blangero, J., and Austgulen, R. Genetic association of preeclampsia to the inflammatory response gene SEPS1. Am J Obstet Gynecol 336: pp e1-336.e5 (2008)

Tonkin, J.N., Knight, B., Curtis, D., Abraham, L.J., and Yeoh, G.C.T. Bone Marrow Cells Play a Minor Role in Chronic Liver Regeneration Induced by a Choline-Deficient, Ethionine Supplemented Diet. Stem Cell Res. (in press) (2008)