W/Prof Geoffrey Stewart
School of Pathology and Laboratory Medicine
- Contact details
- School of Pathology and Laboratory Medicine
The University of Western Australia (M502)
35 Stirling Highway
CRAWLEY WA 6009
- +61 8 9287 6964
- Room G02, Bayliss Building, Crawley campus
- BSc PhD Birm.
- Professor Geoffrey Stewart completed his BSc and PhD at the University of Birmingham in the United Kingdom. Before becoming Head of the School of Biomolecular, Biomedical and Chemical Sciences, he was a Senior Lecturer at UWA and NH&MRC Senior Research Fellow at the Western Australian Institute for Child Health at the Princess Margaret Hospital for Children.
- Key research
- Professor Stewart is an immunochemist by training who has been involved in research on the biochemistry of immunoglobulin function, and house dust mites and pollen allergens for more than 25 years. His early work was the first to show that the integrity of the 2 heavy chain constant region domains of immunoglobulin G was important for the binding of the native protein to Staphylococcal protein A and human rheumatoid factor.
- He then worked on the isolation and characterisation of allergens from the house dust mite and described five of the more than 15 known mite allergen groups, and established their biochemical identities (e.g., cysteine protease, trypsin, amylase). This work contributed to the cloning of the first clinically important aeroallergen namely, Der p 1, in conjunction with collaborators. Work on the mites has now developed into an interest in mite bacteriolytic enzymes and mite endosymbiotic bacteria.
- Professor Stewart has also investigated the possible importance of the biochemical activities of allergens in general, but proteases in particular, in allergic disease. This work lead to an interest in the interaction of proteases with the respiratory epithelium, and the role proteases might play in initiating inflammatory processes in the lung. In this regard, the work contributed to our understanding of the role of a novel group of protease activated receptors in the lung with regard to pro-inflammatory cytokine release and surfactant production.
- More recently, he and his research group have developed an interest in the kallikrein-kinin system and the role of bradykinin in the lung.
- Prof. Stewart has published over 160 manuscripts, which have accumulated a combined citation count of more than 2350. His five most recent publications are:
Robinson C., J. Zhang, J., Stewart, G.A. Potential contributions to the initiation and perpetuation of allergy by interactions between allergens and the airway epithelium. In: The Pulmonary Epithelium. D. Proud Ed, Wiley; pp 301-320 (2008)
Stewart, G.A., Zhang, J., Robinson, C.. The structure and function of allergens. In: Middleton's Allergy. Editors Adkinson NFJ, Busse WW, Bochner BS, Holgate ST, Simons FER, Lemanske RF. Mosby Elsevier; pp 569-608 (2008)
Stewart, G.A., Thompson, P.J., Peden, D., Alexis, N. Allergens and Pollutants. In: Holgate ST, Church MK, Lichtenstein LM, Editors. Allergy. Third ed. London: Mosby Elsevier Ltd; pp 247-287. (2006)
Fink, J., Mathaba, L.T., Stewart, G.A., Graham, P.T., Steer, J.H., Joyce, D.A., McWilliam, A.S. Moraxella catarrhalis stimulates the release of proinflammatory cytokines and prostaglandin E from human respiratory epithelial cells and monocyte-derived macrophages. FEMS Immunology and Medical Microbiology, 46: pp 198-208 (2006)
Sharma, A., Goh, H.L., Asokananthan, N., Bakker, A., Stewart, G.A., Mitchell, H.W. Delayed and persistent suppression of bronchoconstriction by trypsin in the airway lumen. European Respiratory Journal, 27: pp 20-8 (2006)
- Roles, responsibilities and expertise
- Supervised students:
Soh Peng Kai
Julius Varano della Vergiliana
- Funding received
- NHMRC Grant 2006-2009 House mites, bacteria and asthma: The potential modulatory role of gram-positive bacteria
NHMRC Grant 2006-2009 Protease activited receptors present on type II pneumocytes play and important role in pulmonary surfactant production
NHMRC 2008 Equipment Grant
Asthma Foundation of W.A. Grant 2009 The kallikrein-kinin system in asthma: Modulation of high molecular weight kininogen binding proteins by pro-inflammatory stimuli associated with disease.
- Thomas, W.T., Turner, K.J., Stewart, G.A., Simpson, R.J. (1988). Molecular cloning of mite allergens. Australian patent 624077; pending USA, pending Europe, Japan.
Thomas, W.T., Turner, K.J., Stewart, G.A., Simpson, R.J. (1991). Cloning and sequencing of allergens of Dermatophagoides (house dust mite). Australian patent 655599; USA 5433948, 5552, 142, Europe, Japan, Canada, Korea.
- MICR2203 Introductory Immunology (Onshore and Offshore)
IMED3340 Infectious Diseases Part I
PHCY8650 Clinical Science for Pharmacy I
MICR8829 Foundations of Infectious Diseases
MICR3302 Infection and Immunity
MICR3308/3309 Infection and Immunity (Offshore)
- Research profile
Research profile and publications