The University of Western Australia

W/Prof David Joyce

Winthrop Professor
School of Medicine and Pharmacology - Pharmacology, Pharmacy and Anaesthesiology Unit

Contact details

Address

School of Medicine and Pharmacology - Pharmacology, Pharmacy and Anaesthesiology Unit
The University of Western Australia (M510)
35 Stirling Highway
CRAWLEY WA 6009
Australia

Phone

9346 2569

Fax

9346 3469

Email

david.joyce@uwa.edu.au

Qualifications

MB BS W.Aust., MD NSW, FRACP

Biography

Prof. David Joyce heads the Inflammation Pharmacology research laboratory in the Pharmacology unit at UWA, with specific research interests in the drug control of inflammatory diseases. The major areas of research are TNF-alpha suppression, the role of TNF-alpha in inflammatory and survival signalling in inflammatory cells and reactive oxygen interactions with mitochondrial function and intracellular signalling pathways in inflammatory cells.
As well as heading the Inflammation Pharmacology research laboratory, Prof. Joyce is head of the Clinical Pharmacology & Toxicology laboratory at PathWest Laboratory Medicine, and practices clinically in the areas of general internal medicine and clinical pharmacology & toxicology at Sir Charles Gairdner Hospital.
Prof. Joyce also coordinates undergraduate medical teaching in pharmacology and therapeutics at UWA.

Key research

Signalling for activation and survival in macrophage cells

Adaptation of signalling to redox, hypoxic, hyperoxic and nutritional conditions in inflammatory cell environment

Mitochondrial uncoupling as a response to oxygen radical stress

Publications

1.Joyce DA, Bouzahzah B, Fu M, D'Amico M, Albanese C, Steer J, Klein JU, Lee RJ, Segall JD, Westwick JK, Der CJ, Pestell RG. Integration of Rac-dependent regulation of cyclin D1 transcription through a nuclear factor-kB-dependent pathway. J. Biol Chem. 1999;274:25245-9.
2.Zahler MH, Irani A, Malhi H, Reutens AT, Albanese C, Bouzahzah B, Joyce D, Gupta S, Pestell RG. The application of a lentiviral vector for gene transfer in fetal human hepatocytes. J. Gene Med. 2000;2:186-193.
3.Kroeger KM, Steer JH, Joyce DA, Abraham LJ. Effects of stimulus and cell type on the expression of the -308 Tumour Necrosis Factor polymorphism. Cytokine 2000;12:110-119
4.Steer JH, Kroeger KM, Abraham LJ, Joyce DA. Glucocorticoids Suppress TNF-a Expression by Human Monocytic THP-1 Cells by Suppressing Transactivation Through Adjacent NF-kB and c-Jun/ATF-2 Binding Sites in the Promoter. J.Biol.Chem. 2000;275:18432-18440
5.Joyce DA, Albanese C, Steer JH, Fu M, Bouzahzah B, Pestell RG. NF-kB and Cell-Cycle Regulation: The Cyclin Connection. Cytokine and Growth Factor Reviews 2001;12:73-90.
6.Habre W, Bergesio R, Johnson C, Hackett P, Joyce D, Sims C. Pharmacokinetics of ropivacaine following caudal analgesia in children. Paediatr.Anaesth. 2000;10:143-147.
7.Blythe D, Joyce DA. Clearance of arsenic by haemodialysis after acute poisoning with arsenic trioxide. Intensive Care Medicine 2001;27:334.
8.Joyce DA, Gimblett G, Steer JH. Targets of glucocorticoid action on TNF-a release by macrophages. Inflammation Research 2001;50:337-40.
9.Bouzahzah, B., Albanese, C., Ahmed, F., Pixley, F., Lisanti, M.P., Segall, J.D., Condeelis, J., Joyce, D., Minden, A., Der, C.J Chan, A., Symons, M., and Pestell, R.G.. Mol. Med. Rho family GTPases regulate mammary epithelium cell growth and metastasis through distinguishable pathways. Mol. Med 2001;7:816-830.
10.Albanese C, Wu K, D’Amico M, Jarrett C, Attuga F, Joyce D, Hughes J, Hulit J, Sakamaki T, Fu M, Ben Ze’ev A, Bromberg J, Lamberti A, Lin K, Gaynor R, Byers S, Pestell R IKKa activates Tcf signaling and cyclin D1 through an interaction with and phosphorylation of ß-catenin. Molecular Biology of the Cell 2003;14(2):585-99
11.Joyce DA Dusci LJ Hackett LP and Ilett KF. Does your drug and alcohol policy work? Australian Mining 2002; 94:34
12.Fink J, Steer J, Joyce D, McWilliam A, Stewart G. Pro-Inflammatory Effects of Burkholderia cepacia on Cystic Fibrosis Respiratory Epithelium. FEMS Immunology and Medical Microbiology 2003;38:273-282.
13.Wang C, Steer JH, Joyce DA, Yip KHM, Papadimitriou JM, Zheng MH, Xu 12-O-tetradecanoylphorbol-13-acetate (TPA) inhibits osteoclastogenesis by suppressing RANKL-induced activation of NF-kB. J. Bone Mineral Res. 2003;18:2159-68.
14.Kan G, Jenkins I, Rangan G, Woodroffe A, Rhodes H and Joyce DA. Continuous haemodiafiltration compared with intermittent haemodialysis in the treatment of methanol poisoning. Nephrology, Dialysis and Transplantation 2003;18:2665-7
15.Xu J, Wang C, Han R, Phan T, Steer J, Bakker A, Joyce D, Zheng MH. Evidence of Reciprocal Regulation between the High Extracellular Calcium and RANKL Signal Transduction Pathways in RAW Cell Derived Osteoclasts. J. Cellular Physiol. 2005;202:554-62
16.Fink J, Mathaba LT, Stewart GA, Graham P, Steer JH, Joyce DA, McWilliam AS. Moraxella catarrhalis Stimulates the Release of Pro-Inflammatory Cytokines and Prostaglandin E2 from Human Respiratory Epithelial Cells and Monocyte-Derived Macrophages. FEMS Immunology and Medical Microbiology. 2006:46:198-208.
17.Yip KHM, Zheng HM, Feng HT, Steer JH, Joyce DA, Xu J Sesquiterpene lactone parthenolide blocks lipopolysaccharide induced osteolysis via the suppression of NF-kB. J Bone Miner Res. 2004;19:1905-16
18.McDonald CA, Guttinger R, Joyce DA High-Dose Clonidine Withdrawal after Maintenance Prescription: Case report and Guidelines. J Paediatrics Child Health. 2005;41:609-610.
19.Yip KH, Zheng MH, Steer JH, Giardina TM, Han R, Lo SZ, Bakker AJ, Cassady AI, Joyce DA, Xu J. Thapsigargin Modulates Osteoclastogenesis Through the Regulation of RANKL-Induced Signaling Pathways and Reactive Oxygen Species Production. J Bone Miner Res. 2005;20:1462-71
20.Rangan GK, Kan G, Steer JH, Dogra G, Croft KD, Joyce. DA. Altered Expression of Nuclear Factor-kB in Peripheral Blood Mononuclear Cells in Chronic Haemodialysis Patients. Nephrology, Dialysis and Transplantation 2006;21:1137-1139
21.Barnard PJ, Wedlock LE, Baker MV, Berners-Price SJ, Joyce DA, Skelton BW, Steer JH. Luminescence Studies of the Intra-Cellular Distribution of a Dinuclear Gold(I) N heterocyclic Carbene Complex. Angewandte Chemie. 2006;118:6112-6116.
22.Senanayake S, Brownrigg LM, Panicker V, Croft KD, Joyce DA, Steer JH, Puddey IB, Yeap BB. Monocyte-derived macrophages from men and women with Type 2 diabetes mellitus differ in fatty acid composition compared with non-diabetic controls. Diabetes Research and Clinical Practice. 2007;75:292-300.
23.Ang ESM, Zhang P, Steer JH, Tan J, Yip K, Zheng MH, Joyce DA, Xu J Calcium/Calmodulin-dependent kinase activity is required for efficient induction of osteoclast differentiation and bone resorption by Receptor Activator of Nuclear Factor kappa B Ligand (RANKL). J Cellular Physiol. 2007;212:787-795
24.Giardina TM, Steer JH, Lo SZY, Joyce DA. Uncoupling protein-2 accumulates rapidly in the inner mitochondrial membrane during mitochondrial reactive oxygen stress in macrophages. BBA-Bioenergetics. 2008;1777:118-129.
25.Liu M, Sakamaki T, Ju X, Ojeifo J, Wang C, Casamiro M, Katiyar S, Russell R, Joyce D, Albanese C, Pestell RG NF-κB governs the initiation of ErbB2 induced mammary tumorigenesis in inducible transgenic mice. Am. J. Pathol. 2009;174:1910-1920.
26.Feng HT, Cheng T, Steer JH, Joyce DA, Pavlos NJ, Leong CL, Kular J, Liu J, Feng Xu, Zheng MH, Xu J. MEF2 and MITF cooperate with NFATc1 to transactivate the V-ATPase d2 promoter during RANKL-induced osteoclastogenesis . J. Biol. Chem. (Accepted 25 Mar 09)

Roles, responsibilities and expertise

Undergraduate teaching in medicine, science, dentistry
Postgraduate supervision
Clinical Practice

Funding received

G. K. Rangan, D.A. Joyce. Regulation of tubular epithelial cell proliferation and cyclin D1 by NF-kB/Rel in proteinuric chronic renal diseases. ($35,000). Medical Research Foundation of WA. 2001
M-H Zheng, DA Joyce, Langdon W et al. Large Equipment Grant: BMG Polarstar Optima Microplate Fluorimeter/Luminometer ($82,045). University of WA Permanent Endowment for Medical Research. 2003
J. Xu, D.A. Joyce. Inhibition of RANKL-induced osteoclastogenesis through modulation of NF-кB signalling by PKC isoforms and parthenolide ($20,000). Arthritis Foundation of Western Australia. 2005
G. K. Rangan, D.A. Joyce, JH Steer. Regulation of tubular epithelial cell proliferation and cyclin D1 by NF-kB/Rel in proteinuric chronic renal diseases. ($10,000). Fremantle Hospital Medical Research Foundation. 2002
D.A. Joyce, J.H. Steer. Rac-ROS-NF-kB Pathways in Survival and Growth of Fibroblasts and Macrophages in Chronic Inflammatory Synovial Disease ($10,000). Sir Charles Gairdner Hospital Research Foundation. 2002
DA Joyce; PJ Henry. Macrophage uncoupling protein-2 regulation and expression in inflammatory joint disease and hyperoxic lung damage ($259,250). National Health & Medical Research Council. 2009 -2011
S Ching, C Newbound, DA Joyce, J Beilby. The development of improved pharmacogenomic reporting of thiopurine methyl transferase (TPMT) enzyme activity and genotypes. ($13,500). PathWest QEII Research Grant. 2009 -2010

Teaching

Undergraduate: IMED3345; IMED4451; IMED4452: PHAR8502; PHAR2230; PHAR3302; IDNT3382

Current external positions

Head of the Clinical Pharmacology & Toxicology laboratory at PathWest Laboratory Medicine
Head of the Department of Clinical Pharmacology & Toxicology laboratory at Sir Charles Gairdner Hospital
Consultant Physician, General Internal Medicine, Sir Charles Gairdner Hospital

Research profile

Research profile and publications