The University of Western Australia
Professor Charles Bond
Professorial Fellow
Contact details
| Address | Biochemistry and Molecular Biology The University of Western Australia (M310) 35 Stirling Highway CRAWLEY WA 6009 Australia |
|---|---|
| Phone | 6488 4406 |
| charles.bond@uwa.edu.au | |
| Personal homepage | www.crystal.uwa.edu.au/px/charlie |
Location
Room 416, Molecular and Chemical Sciences Building, Crawley campus
Biography
Charlie Bond first became interested in chemistry at school in the United Kingdom and went on to study at the University in Manchester. After completing his PhD on the structure of proteins he pursued this field as a post-doctoral researcher in Sydney and as a research fellow at the School of Life Sciences, University of Dundee, UK. He was recruited to UWA as a structural biologist in 2006. In addition to researching the structure of proteins he has also developed and published related computer software programs.
Key research
- As a structural biologist, Prof. Bond studies the three dimensional structure of biological molecules, such as nucleic acids and proteins, which helps to explain how the molecules function. The applications of Prof. Bond’s studies are very broad and far reaching. Protein structures can be used as a basis to design drugs to treat infectious diseases, and researching how proteins contribute to errors in DNA and RNA expression increases our understanding of how cancers and other disorders are caused, and how they might be treated.
Major research interests
- Enzyme structure, function and inhibition
- Mechanisms of DNA repair
- Protein crystallography
- Protein–nucleic acid interactions
- Structural biology
Qualifications
BSc PhD Manc., MRSC
Publications
Iyer, K. S., Bond, C. S., Saunders, M. and Raston, C. L. Confinement of Silver Triangles in Silver Nanoplates Templated by Duplex DNA, Crystal Growth and Design, 8: pp 1451-1453 (2008)
Delannoy, E., Stanley, W.A., Bond, C.S., and Small, I.D. Pentatricopeptide repeat (PPR) proteins as sequence-specificity factors in post-transcriptional processes in organelles. Biochemical Society Transactions, 35: pp 1643-1647 (2007)
Gabrielsen, M., Kaiser, J., Rohdich, F., Eisenreich, W., Laupitz, R., Bacher, A., Bond, C. S., Hunter, W. N. The crystal structure of a plant 2C-methyl-D-erythritol 4-phosphate cytidylyltransferase exhibits a distinct quaternary structure compared to bacterial homologues and a possible role in feedback regulation for cytidine monophosphate, FEBS Journal, 273: pp 1065-73 (2006)
Ariza, A., Vickers, T. J., Greig, N., Armour, K. A., Dixon, M. J., Eggleston, I. M., Fairlamb, A. H., Bond, C. S. Specificity of the trypanothione-dependent Leishmania major glyoxalase I: structure and biochemical comparison with the human enzyme, Molecular Microbiology, 59: pp 1239-1248 (2006)
Kemp, L. E., Alphey, M. S., Bond, C. S., Ferguson, M. A., Hecht, S., Bacher, A., Eisenreich, W., Rohdich, F., Hunter, W. N. The identification of isoprenoids that bind in the intersubunit cavity of Escherichia coli 2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase by complementary biophysical methods", Acta Crystallography D Biological Crystallography, 61: pp 45-52 (2005)
Graham, S. C., Bond, C. S., Freeman, H. C., Guss, J. M. Structural and functional implications of metal ion selection in aminopeptidase p, a metalloprotease with a dinuclear metal center, Biochemistry, 44: pp 13820-36 (2005)
Fox, A. H., Bond, C. S., Lamond, A. I. P54nrb forms a heterodimer with PSP1 that localises to paraspeckles in a RNA-dependent manner, Molecular Biology of the Cell, 16: pp 5304-15 (2005)
Ariza, A., Vickers, T. J., Greig, N., Fairlamb, A. H., Bond, C. S. Crystallization and preliminary X-ray analysis of Leishmania major glyoxalase I, Acta Crystallography F, 61: pp 769-772 (2005)
Ariza, A., Richard, D. J., White, M. F., Bond, C. S. Conformational flexibility revealed by the crystal structure of a crenarchaeal RadA, Nucleic Acids Research, 33: pp 1465-73 (2005)
Middleton, C. L., Parker, J. L., Richard, D. J., White, M. F., Bond, C. S. Substrate recognition and catalysis by the Holliday junction resolving enzyme Hje, Nucleic Acids Research, 32: pp 5442-51 (2004)
Saravanamuthu, A., Vickers, T. J., Bond, C. S., Peterson, M. R., Hunter, W. N., Fairlamb, A. H. Two interacting binding sites for quinacrine derivatives in the active site of trypanothione reductase: a template for drug design, Journal of Biological Chemistry, 279: pp 29493-500 (2004)
Gabrielsen, M., Bond, C. S., Hallyburton, I., Hecht, S., Bacher, A., Eisenreich, W., Rohdich, F., Hunter, W. N. Hexameric assembly of the bifunctional methylerythritol 2,4-cyclodiphosphate synthase and protein-protein associations in the deoxy-xylulose-dependent pathway of isoprenoid precursor biosynthesis, Journal of Biological Chemistry, 279: pp 52753-61 (2004)
Middleton, C. L., Parker, J. L., Richard, D. J., White, M. F., Bond, C. S. Crystallization and preliminary X-ray diffraction studies of Hje, a Holliday junction resolving enzyme from Sulfolobus solfataricus, Acta Crystallography D Biological Crystallography, 59: pp 171-3 (2003)
Hunter, W. N., Bond, C. S., Gabrielsen, M., Kemp, L. E. Structure and reactivity in the non-mevalonate pathway of isoprenoid biosynthesis, Biochemical Society Transactions, 31: pp 537-42 (2003)
Shaw, M. P., Bond, C. S., Roper, J. R., Gourley, D. G., Ferguson, M. A., Hunter, W. N. High-resolution crystal structure of Trypanosoma brucei UDP-galactose 4'-epimerase: a potential target for structure-based development of novel trypanocides, Molecular and Biochemical Parasitology, 126: pp 173-80 (2003)
Kemp, L. E., Bond, C. S., Hunter, W. N. Structure of a tetragonal crystal form of Escherichia coli 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, Acta Crystallography D Biological Crystallography, 59: pp 607-10 (2003)
Hunter, W. N., Alphey, M. S., Bond, C. S., Schuettelkopf, A. W. Targeting metabolic pathways in microbial pathogens: oxidative stress and anti-folate drug resistance in trypanosomatids, Biochemical Society Transactions, 31: pp 607-10 (2003)
Bond, C. S. Easy editing of Protein Data Bank formatted files with EMACS, Journal of Applied Crystallography, 36: pp 350-351 (2003)
Bond, C. S. TopDraw: a sketchpad for protein structure topology cartoons, Bioinformatics, 19: pp 311-2 (2003)
Alphey, M. S., Gabrielsen, M., Micossi, E., Leonard, G. A., McSweeney, S. M., Ravelli, R. B., Tetaud, E., Fairlamb, A. H., Bond, C. S., Hunter, W. N. Tryparedoxins from Crithidia fasciculata and Trypanosoma brucei: photoreduction of the redox disulfide using synchrotron radiation and evidence for a conformational switch implicated in function, Journal of Biological Chemistry, 278: pp 25919-25 (2003)
Kvaratskhelia, M., Wardleworth, B. N., Bond, C. S., Fogg, J. M., Lilley, D. M., White, M. F. Holliday junction resolution is modulated by archaeal chromatin components in vitro, Journal of Biological Chemistry, 277: pp 2992-6 (2002)
Hall, D. R., Bond, C. S., Leonard, G. A., Watt, C. I., Berry, A., Hunter, W. N. Structure of tagatose-1,6-bisphosphate aldolase. Insight into chiral discrimination, mechanism, and specificity of class II aldolases, Journal of Biological Chemistry, 277: pp 22018-24 (2002)
Bond, C. S., White, M. F., Hunter, W. N. Mechanistic implications for Escherichia coli cofactor-dependent phosphoglycerate mutase based on the high-resolution crystal structure of a vanadate complex, Journal of Molecular Biology, 316: pp 1071-81 (2002)
Kemp, L. E., Bond, C. S., Hunter, W. N. Structure of 2C-methyl-D-erythritol 2,4- cyclodiphosphate synthase: an essential enzyme for isoprenoid biosynthesis and target for antimicrobial drug development, Proceedings of the Natural Acadamy of Sciences USA, 99: pp 6591-6 (2002)
Mehlert, A., Bond, C. S., Ferguson, M. A. The glycoforms of a Trypanosoma brucei variant surface glycoprotein and molecular modeling of a glycosylated surface coat, Glycobiology, 12: pp 607-12 (2002)
Kemp, L. E., Bond, C. S., Hunter, W. N. Crystallization and preliminary X-ray diffraction studies of recombinant Escherichia coli 4-diphosphocytidyl-2-C-methyl-D-erythritol synthetase, Acta Crystallography D Biological Crystallography, 57: pp 1189-91 (2001)
Bond, C. S., White, M. F., Hunter, W. N. High resolution structure of the phosphohistidine-activated form of Escherichia coli cofactor-dependent phosphoglycerate mutase, Journal of Biological Chemistry, 276: pp 3247-53 (2001)
Bond, C. S., Shaw, M. P., Alphey, M. S., Hunter, W. N. Structure of the macrocycle thiostrepton solved using the anomalous dispersion contribution of sulfur, Acta Crystallography D Biological Crystallography, 57: pp 755-8 (2001)
Bond, C. S., Kvaratskhelia, M., Richard, D., White, M. F., Hunter, W. N. Structure of Hjc, a Holliday junction resolvase, from Sulfolobus solfataricus, Proceedings of the Natural Acadamy of Sciences USA, 98: pp 5509-14 (2001)
Bond, C. S., Blankenship, R. E., Freeman, H. C., Guss, J. M., Maher, M. J., Selvaraj, F. M., Wilce, M. C., Willingham, K. M.Crystal structure of auracyanin, a "blue" copper protein from the green thermophilic photosynthetic bacterium Chloroflexus aurantiacus, Journal of Molecular Biology, 306: pp 47-67 (2001)
Alphey, M. S., Bond, C. S., Tetaud, E., Fairlamb, A. H., Hunter, W. N. The structure of reduced tryparedoxin peroxidase reveals a decamer and insight into reactivity of 2Cys-peroxiredoxins, Journal of Molecular Biology, 300: pp 903-16 (2000)
Xiao, Z., Maher, M. J., Cross, M., Bond, C. S., Guss, J. M., Wedd, A. G. Mutation of the surface valine residues 8 and 44 in the rubredoxin from Clostridium pasteurianum: solvent access versus structural changes as determinants of reversible potential, Journal of Biological Inorganic Chemistry, 5: pp 75-84 (2000)
Turner, C. T., Hopwood, J. J., Bond, C. S., Brooks, D. A. Immune response to enzyme replacement therapy: 4-sulfatase epitope reactivity of plasma antibodies from MPS VI cats, Molecular Genetetics and Metabolism, 67: pp 194-205 (1999)
Bond, C. S., Zhang, Y., Berriman, M., Cunningham, M. L., Fairlamb, A. H., Hunter, W. N. Crystal structure of Trypanosoma cruzi trypanothione reductase in complex with trypanothione, and the structure-based discovery of new natural product inhibitors, Structure Fold Des, 7: pp 81-9 (1999)
Bond, C. S., Bendall, D. S., Freeman, H. C., Guss, J. M., Howe, C. J., Wagner, M. J., Wilce, M. C. The structure of plastocyanin from the cyanobacterium Phormidium laminosum, Acta Crystallography D Biol Crystallography, 55 ( Pt 2): pp 414-21 (1999)
Wilce, M. C., Bond, C. S., Dixon, N. E., Freeman, H. C., Guss, J. M., Lilley, P. E., Wilce, J. A. Structure and mechanism of a proline-specific aminopeptidase from Escherichia coli,Proceedings of the Natural Acadamy of Sciences USA, 95: pp 3472-7 (1998)
Bond, C. S., Clements, P. R., Ashby, S. J., Collyer, C. A., Harrop, S. J., Hopwood, J. J., Guss, J. M. Structure of a human lysosomal sulfatase, Structure, 5: pp 277-89 (1997)
Zhang, Y., Bond, C. S., Bailey, S., Cunningham, M. L., Fairlamb, A. H., Hunter, W. N. The crystal structure of trypanothione reductase from the human pathogen Trypanosoma cruzi at 2.3 A resolution, Protein Science, 5: pp 52-61 (1996)
Hunter, W. N., Zhang, Y., Bond, C. S., Ralph, A. C., Bailey, S., Cunningham, M., Smith, K., Borges, A., Tovar, J., Fairlamb, A. H. Structural Characterization of Trypanothione Reductase; a Specific Target for Anti-trypanosomal Drug Design, Perspectives on Protein Engineering and Complementary Techniques, Geisow, M.J., Repton, R., Eds., Mayflower Worldwide Ltd, Birmingham, pp 253-256 (1996)
Bond, C. S., Fairlamb, A. H., Hunter, W.N.A. Comparison of Two Independently Determined Structures of Trypanothione Reductase from Crithidia fasciculata, Acta Crystallography D Biological Crystallography, 51: pp 567-574 (1995)
Bond, C. S., Leonard, G. A., Regan, A. C., Hunter, W. N., Andrews, F. P. Chiral Tetrahydro-gamma-pyranocarboxylate Ester for Asymmetric Nazarov Cyclization, Acta Crystallography C, 50: pp 133-136 (1994)
Zhang, Y., Bailey, S., Naismith, J. H., Bond, C. S., Habash, J., McLaughlin, P., Papiz, M. Z., Borges, A., Cunningham, M., Fairlamb, A. H. Trypanosoma cruzi trypanothione reductase. Crystallization, unit cell dimensions and structure solution, Journal of Molecular Biology, 232: pp 1217-20 (1993)
Delannoy, E., Stanley, W.A., Bond, C.S., and Small, I.D. Pentatricopeptide repeat (PPR) proteins as sequence-specificity factors in post-transcriptional processes in organelles. Biochemical Society Transactions, 35: pp 1643-1647 (2007)
Gabrielsen, M., Kaiser, J., Rohdich, F., Eisenreich, W., Laupitz, R., Bacher, A., Bond, C. S., Hunter, W. N. The crystal structure of a plant 2C-methyl-D-erythritol 4-phosphate cytidylyltransferase exhibits a distinct quaternary structure compared to bacterial homologues and a possible role in feedback regulation for cytidine monophosphate, FEBS Journal, 273: pp 1065-73 (2006)
Ariza, A., Vickers, T. J., Greig, N., Armour, K. A., Dixon, M. J., Eggleston, I. M., Fairlamb, A. H., Bond, C. S. Specificity of the trypanothione-dependent Leishmania major glyoxalase I: structure and biochemical comparison with the human enzyme, Molecular Microbiology, 59: pp 1239-1248 (2006)
Kemp, L. E., Alphey, M. S., Bond, C. S., Ferguson, M. A., Hecht, S., Bacher, A., Eisenreich, W., Rohdich, F., Hunter, W. N. The identification of isoprenoids that bind in the intersubunit cavity of Escherichia coli 2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase by complementary biophysical methods", Acta Crystallography D Biological Crystallography, 61: pp 45-52 (2005)
Graham, S. C., Bond, C. S., Freeman, H. C., Guss, J. M. Structural and functional implications of metal ion selection in aminopeptidase p, a metalloprotease with a dinuclear metal center, Biochemistry, 44: pp 13820-36 (2005)
Fox, A. H., Bond, C. S., Lamond, A. I. P54nrb forms a heterodimer with PSP1 that localises to paraspeckles in a RNA-dependent manner, Molecular Biology of the Cell, 16: pp 5304-15 (2005)
Ariza, A., Vickers, T. J., Greig, N., Fairlamb, A. H., Bond, C. S. Crystallization and preliminary X-ray analysis of Leishmania major glyoxalase I, Acta Crystallography F, 61: pp 769-772 (2005)
Ariza, A., Richard, D. J., White, M. F., Bond, C. S. Conformational flexibility revealed by the crystal structure of a crenarchaeal RadA, Nucleic Acids Research, 33: pp 1465-73 (2005)
Middleton, C. L., Parker, J. L., Richard, D. J., White, M. F., Bond, C. S. Substrate recognition and catalysis by the Holliday junction resolving enzyme Hje, Nucleic Acids Research, 32: pp 5442-51 (2004)
Saravanamuthu, A., Vickers, T. J., Bond, C. S., Peterson, M. R., Hunter, W. N., Fairlamb, A. H. Two interacting binding sites for quinacrine derivatives in the active site of trypanothione reductase: a template for drug design, Journal of Biological Chemistry, 279: pp 29493-500 (2004)
Gabrielsen, M., Bond, C. S., Hallyburton, I., Hecht, S., Bacher, A., Eisenreich, W., Rohdich, F., Hunter, W. N. Hexameric assembly of the bifunctional methylerythritol 2,4-cyclodiphosphate synthase and protein-protein associations in the deoxy-xylulose-dependent pathway of isoprenoid precursor biosynthesis, Journal of Biological Chemistry, 279: pp 52753-61 (2004)
Middleton, C. L., Parker, J. L., Richard, D. J., White, M. F., Bond, C. S. Crystallization and preliminary X-ray diffraction studies of Hje, a Holliday junction resolving enzyme from Sulfolobus solfataricus, Acta Crystallography D Biological Crystallography, 59: pp 171-3 (2003)
Hunter, W. N., Bond, C. S., Gabrielsen, M., Kemp, L. E. Structure and reactivity in the non-mevalonate pathway of isoprenoid biosynthesis, Biochemical Society Transactions, 31: pp 537-42 (2003)
Shaw, M. P., Bond, C. S., Roper, J. R., Gourley, D. G., Ferguson, M. A., Hunter, W. N. High-resolution crystal structure of Trypanosoma brucei UDP-galactose 4'-epimerase: a potential target for structure-based development of novel trypanocides, Molecular and Biochemical Parasitology, 126: pp 173-80 (2003)
Kemp, L. E., Bond, C. S., Hunter, W. N. Structure of a tetragonal crystal form of Escherichia coli 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, Acta Crystallography D Biological Crystallography, 59: pp 607-10 (2003)
Hunter, W. N., Alphey, M. S., Bond, C. S., Schuettelkopf, A. W. Targeting metabolic pathways in microbial pathogens: oxidative stress and anti-folate drug resistance in trypanosomatids, Biochemical Society Transactions, 31: pp 607-10 (2003)
Bond, C. S. Easy editing of Protein Data Bank formatted files with EMACS, Journal of Applied Crystallography, 36: pp 350-351 (2003)
Bond, C. S. TopDraw: a sketchpad for protein structure topology cartoons, Bioinformatics, 19: pp 311-2 (2003)
Alphey, M. S., Gabrielsen, M., Micossi, E., Leonard, G. A., McSweeney, S. M., Ravelli, R. B., Tetaud, E., Fairlamb, A. H., Bond, C. S., Hunter, W. N. Tryparedoxins from Crithidia fasciculata and Trypanosoma brucei: photoreduction of the redox disulfide using synchrotron radiation and evidence for a conformational switch implicated in function, Journal of Biological Chemistry, 278: pp 25919-25 (2003)
Kvaratskhelia, M., Wardleworth, B. N., Bond, C. S., Fogg, J. M., Lilley, D. M., White, M. F. Holliday junction resolution is modulated by archaeal chromatin components in vitro, Journal of Biological Chemistry, 277: pp 2992-6 (2002)
Hall, D. R., Bond, C. S., Leonard, G. A., Watt, C. I., Berry, A., Hunter, W. N. Structure of tagatose-1,6-bisphosphate aldolase. Insight into chiral discrimination, mechanism, and specificity of class II aldolases, Journal of Biological Chemistry, 277: pp 22018-24 (2002)
Bond, C. S., White, M. F., Hunter, W. N. Mechanistic implications for Escherichia coli cofactor-dependent phosphoglycerate mutase based on the high-resolution crystal structure of a vanadate complex, Journal of Molecular Biology, 316: pp 1071-81 (2002)
Kemp, L. E., Bond, C. S., Hunter, W. N. Structure of 2C-methyl-D-erythritol 2,4- cyclodiphosphate synthase: an essential enzyme for isoprenoid biosynthesis and target for antimicrobial drug development, Proceedings of the Natural Acadamy of Sciences USA, 99: pp 6591-6 (2002)
Mehlert, A., Bond, C. S., Ferguson, M. A. The glycoforms of a Trypanosoma brucei variant surface glycoprotein and molecular modeling of a glycosylated surface coat, Glycobiology, 12: pp 607-12 (2002)
Kemp, L. E., Bond, C. S., Hunter, W. N. Crystallization and preliminary X-ray diffraction studies of recombinant Escherichia coli 4-diphosphocytidyl-2-C-methyl-D-erythritol synthetase, Acta Crystallography D Biological Crystallography, 57: pp 1189-91 (2001)
Bond, C. S., White, M. F., Hunter, W. N. High resolution structure of the phosphohistidine-activated form of Escherichia coli cofactor-dependent phosphoglycerate mutase, Journal of Biological Chemistry, 276: pp 3247-53 (2001)
Bond, C. S., Shaw, M. P., Alphey, M. S., Hunter, W. N. Structure of the macrocycle thiostrepton solved using the anomalous dispersion contribution of sulfur, Acta Crystallography D Biological Crystallography, 57: pp 755-8 (2001)
Bond, C. S., Kvaratskhelia, M., Richard, D., White, M. F., Hunter, W. N. Structure of Hjc, a Holliday junction resolvase, from Sulfolobus solfataricus, Proceedings of the Natural Acadamy of Sciences USA, 98: pp 5509-14 (2001)
Bond, C. S., Blankenship, R. E., Freeman, H. C., Guss, J. M., Maher, M. J., Selvaraj, F. M., Wilce, M. C., Willingham, K. M.Crystal structure of auracyanin, a "blue" copper protein from the green thermophilic photosynthetic bacterium Chloroflexus aurantiacus, Journal of Molecular Biology, 306: pp 47-67 (2001)
Alphey, M. S., Bond, C. S., Tetaud, E., Fairlamb, A. H., Hunter, W. N. The structure of reduced tryparedoxin peroxidase reveals a decamer and insight into reactivity of 2Cys-peroxiredoxins, Journal of Molecular Biology, 300: pp 903-16 (2000)
Xiao, Z., Maher, M. J., Cross, M., Bond, C. S., Guss, J. M., Wedd, A. G. Mutation of the surface valine residues 8 and 44 in the rubredoxin from Clostridium pasteurianum: solvent access versus structural changes as determinants of reversible potential, Journal of Biological Inorganic Chemistry, 5: pp 75-84 (2000)
Turner, C. T., Hopwood, J. J., Bond, C. S., Brooks, D. A. Immune response to enzyme replacement therapy: 4-sulfatase epitope reactivity of plasma antibodies from MPS VI cats, Molecular Genetetics and Metabolism, 67: pp 194-205 (1999)
Bond, C. S., Zhang, Y., Berriman, M., Cunningham, M. L., Fairlamb, A. H., Hunter, W. N. Crystal structure of Trypanosoma cruzi trypanothione reductase in complex with trypanothione, and the structure-based discovery of new natural product inhibitors, Structure Fold Des, 7: pp 81-9 (1999)
Bond, C. S., Bendall, D. S., Freeman, H. C., Guss, J. M., Howe, C. J., Wagner, M. J., Wilce, M. C. The structure of plastocyanin from the cyanobacterium Phormidium laminosum, Acta Crystallography D Biol Crystallography, 55 ( Pt 2): pp 414-21 (1999)
Wilce, M. C., Bond, C. S., Dixon, N. E., Freeman, H. C., Guss, J. M., Lilley, P. E., Wilce, J. A. Structure and mechanism of a proline-specific aminopeptidase from Escherichia coli,Proceedings of the Natural Acadamy of Sciences USA, 95: pp 3472-7 (1998)
Bond, C. S., Clements, P. R., Ashby, S. J., Collyer, C. A., Harrop, S. J., Hopwood, J. J., Guss, J. M. Structure of a human lysosomal sulfatase, Structure, 5: pp 277-89 (1997)
Zhang, Y., Bond, C. S., Bailey, S., Cunningham, M. L., Fairlamb, A. H., Hunter, W. N. The crystal structure of trypanothione reductase from the human pathogen Trypanosoma cruzi at 2.3 A resolution, Protein Science, 5: pp 52-61 (1996)
Hunter, W. N., Zhang, Y., Bond, C. S., Ralph, A. C., Bailey, S., Cunningham, M., Smith, K., Borges, A., Tovar, J., Fairlamb, A. H. Structural Characterization of Trypanothione Reductase; a Specific Target for Anti-trypanosomal Drug Design, Perspectives on Protein Engineering and Complementary Techniques, Geisow, M.J., Repton, R., Eds., Mayflower Worldwide Ltd, Birmingham, pp 253-256 (1996)
Bond, C. S., Fairlamb, A. H., Hunter, W.N.A. Comparison of Two Independently Determined Structures of Trypanothione Reductase from Crithidia fasciculata, Acta Crystallography D Biological Crystallography, 51: pp 567-574 (1995)
Bond, C. S., Leonard, G. A., Regan, A. C., Hunter, W. N., Andrews, F. P. Chiral Tetrahydro-gamma-pyranocarboxylate Ester for Asymmetric Nazarov Cyclization, Acta Crystallography C, 50: pp 133-136 (1994)
Zhang, Y., Bailey, S., Naismith, J. H., Bond, C. S., Habash, J., McLaughlin, P., Papiz, M. Z., Borges, A., Cunningham, M., Fairlamb, A. H. Trypanosoma cruzi trypanothione reductase. Crystallization, unit cell dimensions and structure solution, Journal of Molecular Biology, 232: pp 1217-20 (1993)
Future research
Prof Bond has the following avilable student projects:
RNA binding properties of the ROP-protein (Honours)
Structural studies of PPR proteins (PhD)
RNA binding properties of the ROP-protein (Honours)
Structural studies of PPR proteins (PhD)
Funding received
NHMRC Project Grant
Memberships
Australian Society for Biochemistry and Molecular Biology
Biochemical Society
British Crystallographic Association
Royal Society of Chemistry
Society of Crystallographers in Australia and New Zealand
Western Australia Protein Group
Biochemical Society
British Crystallographic Association
Royal Society of Chemistry
Society of Crystallographers in Australia and New Zealand
Western Australia Protein Group
Teaching
BIOC3351 Molecular and Structural Biochemistry
CHEM3309 Chemistry in the Workplace
IMED1113 Molecules, Genes and Cells
Graduate Entry Medical Program (GEMP)
Prof Bond also supervises:
Ash Tie (Hons) Structural studies of a trypanosomal glyoxalase 1
James Allan (Hons) Investigating protein-protein interactions involved in leukemia
CHEM3309 Chemistry in the Workplace
IMED1113 Molecules, Genes and Cells
Graduate Entry Medical Program (GEMP)
Prof Bond also supervises:
Ash Tie (Hons) Structural studies of a trypanosomal glyoxalase 1
James Allan (Hons) Investigating protein-protein interactions involved in leukemia
Current projects
Drug design project to identify the inhibitors for glyoxalase-1 from the parasites that cause sleeping sickness and Chagas' disease.
Researching how nucleic acid binding proteins recognize DNA and RNA in plants, humans, bacteria and archaea.
Research Collaborations and Affiliations
Dr Iyer Swaminatha, Centre for Strategic Nanofabrication
Dr Ian Small, ARC Centre for Excellence in Plant Energy Biology
Dr Will Stanley, ARC Centre for Excellence in Plant Energy Biology
Dr Archa Fox, Western Australian Institute for Medical Research (WAIMR)
Dr Louise Winteringham, Western Australian Institute for Medical Research (WAIMR)
Researching how nucleic acid binding proteins recognize DNA and RNA in plants, humans, bacteria and archaea.
Research Collaborations and Affiliations
Dr Iyer Swaminatha, Centre for Strategic Nanofabrication
Dr Ian Small, ARC Centre for Excellence in Plant Energy Biology
Dr Will Stanley, ARC Centre for Excellence in Plant Energy Biology
Dr Archa Fox, Western Australian Institute for Medical Research (WAIMR)
Dr Louise Winteringham, Western Australian Institute for Medical Research (WAIMR)
Research profile
