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The University of Western Australia
UWA Staff Profile
Dr Adrian Scaffidi
Research Associate
Contact details
| Address | Chemistry The University of Western Australia (M310) 35 Stirling Highway CRAWLEY WA 6009 Australia |
|---|---|
| Phone | 6488 1755 |
| Fax | 6488 4444 |
| adrian.scaffidi@uwa.edu.au |
Location
Room 414, Molecular and Chemical Sciences Building, Crawley campus
Biography
Dr Adrian Scaffidi completed a Bachelor of Science majoring in Chemistry (Honours) and Mathematics followed by a PhD from The University of Western Australia. Upon the completion of his studies, Dr Scaffidi worked for drug discovery company Epichem prior to accepting a Research Associate position at UWA.
Key research
- Karrikins are a new class of germination stimulants present in smoke that have attracted much interest due to their ability to promote the germination of species present in both fire and non-fire prone regions at remarkably low concentrations. Karrikins provide an opportunity for improving the restoration of natural and disturbed ecosystems by increasing the germination rate of various species, in addition to plant conservation and weed control. My research aims to further understand the role of karrikins in Nature by investigating their metabolism, molecular targets and environmental fate.
- Collaborators
- Dr Gavin Flematti, Chemistry UWA
- Dr David Nelson, ARC Center of Excellence UWA
- Dr David Merritt, Kings Park and Botanical Garden
- Dr Jason Stevens, Kings Park and Botanical Garden
Publications
K. A. Stubbs, A. Scaffidi, A. W. Debowski, B. L. Mark, R. V. Stick, D. J. Vocadlo, Synthesis and Use of Mechanism-based Protein-profiling Probes for Retaining β-D-Gucosaminidases Facilitate Identification of Pseudomonas Aeruginosa NagZ, J. Am. Chem. Soc., 2008, 130, 327.
A. Scaffidi, K. A. Stubbs, D. J. Vocadlo, R. V. Stick, The Synthesis and Biological Evaluation of Some Carbocyclic Analogues of PUGNAc, Carbohydr. Res., 2008, 343, 2744.
A. Scaffidi, K. A. Stubbs, R. J. Dennis, E. J. Taylor, G. J. Davies, D. J. Vocadlo, R. V. Stick, A 1-Acetamido Derivative of 6-epi-Valienamine: An Inhibitor of a Diverse Group of β-N-Acetylglucosaminidases, Org. Biomol. Chem., 2007, 5, 3013.
A. Scaffidi, R. V. Stick and K. A. Stubbs, Synthesis of Some Glycosylated Derivatives of 2-Deoxy-2-fluoro-β-laminaribiosyl Fluoride: Another Success for Glycosynthases, Aust, J. Chem. 2007, 60, 83.
V. A. Money, N. L. Smith, A. Scaffidi, R. V. Stick, H. J. Gilbert, and G. J. Davies, Substrate Distortion by a Lichenase Highlights the Different Conformational Itineraries Harnessed by Related Glycoside Hydrolases, Angew. Chem. Int. Ed. Engl. 2006, 45, 5136.
A. Scaffidi and R. V. Stick, Glycosynthase-Assisted Synthesis of Some Glycosylated scyllo-Inositols, Aust, J. Chem. 2006, 59, 894.
A. Scaffidi, B. W. Skelton, R. V. Stick and A. H. White, An Expansion of the Role of the Corey–Link Reaction for the Synthesis of α-Substituted Carboxylic Acid Esters, Aust, J. Chem. 2006, 59, 426.
A. Scaffidi, B. W. Skelton, R. V. Stick and A. H. White, Structural Characterisation of a Pentapeptide Derived from a Novel Carbohydrate α-Amino Acid, Aust, J. Chem. 2006, 60, 93.
A. Scaffidi, B. W. Skelton, R. V. Stick and A. H. White, The Synthesis of Some Oligopeptides Derived from Novel Carbohydrate α-Amino Acids, Aust, J. Chem. 2004, 57, 733.
A. Scaffidi, B. W. Skelton, R. V. Stick and A. H. White, The Synthesis of Carbohydrate α-Amino Acids Utilising the Corey–Link Reaction, Aust, J. Chem. 2004, 57, 723.
G. S. Forman, A. Scaffidi and R. V. Stick, An Alternative Synthesis of Some Carbohydrate α-Amino Acids, Aust, J. Chem. 2004, 57, 25.
A. Scaffidi, K. A. Stubbs, D. J. Vocadlo, R. V. Stick, The Synthesis and Biological Evaluation of Some Carbocyclic Analogues of PUGNAc, Carbohydr. Res., 2008, 343, 2744.
A. Scaffidi, K. A. Stubbs, R. J. Dennis, E. J. Taylor, G. J. Davies, D. J. Vocadlo, R. V. Stick, A 1-Acetamido Derivative of 6-epi-Valienamine: An Inhibitor of a Diverse Group of β-N-Acetylglucosaminidases, Org. Biomol. Chem., 2007, 5, 3013.
A. Scaffidi, R. V. Stick and K. A. Stubbs, Synthesis of Some Glycosylated Derivatives of 2-Deoxy-2-fluoro-β-laminaribiosyl Fluoride: Another Success for Glycosynthases, Aust, J. Chem. 2007, 60, 83.
V. A. Money, N. L. Smith, A. Scaffidi, R. V. Stick, H. J. Gilbert, and G. J. Davies, Substrate Distortion by a Lichenase Highlights the Different Conformational Itineraries Harnessed by Related Glycoside Hydrolases, Angew. Chem. Int. Ed. Engl. 2006, 45, 5136.
A. Scaffidi and R. V. Stick, Glycosynthase-Assisted Synthesis of Some Glycosylated scyllo-Inositols, Aust, J. Chem. 2006, 59, 894.
A. Scaffidi, B. W. Skelton, R. V. Stick and A. H. White, An Expansion of the Role of the Corey–Link Reaction for the Synthesis of α-Substituted Carboxylic Acid Esters, Aust, J. Chem. 2006, 59, 426.
A. Scaffidi, B. W. Skelton, R. V. Stick and A. H. White, Structural Characterisation of a Pentapeptide Derived from a Novel Carbohydrate α-Amino Acid, Aust, J. Chem. 2006, 60, 93.
A. Scaffidi, B. W. Skelton, R. V. Stick and A. H. White, The Synthesis of Some Oligopeptides Derived from Novel Carbohydrate α-Amino Acids, Aust, J. Chem. 2004, 57, 733.
A. Scaffidi, B. W. Skelton, R. V. Stick and A. H. White, The Synthesis of Carbohydrate α-Amino Acids Utilising the Corey–Link Reaction, Aust, J. Chem. 2004, 57, 723.
G. S. Forman, A. Scaffidi and R. V. Stick, An Alternative Synthesis of Some Carbohydrate α-Amino Acids, Aust, J. Chem. 2004, 57, 25.
Funding received
UWA Research Development Award
Memberships
Royal Australian Chemical Institute
Research profile
The University of Western Australia
The University of Western Australia
University information CRICOS Code: 00126G
This Page
Last updated:
Tuesday, 14 July, 2009 1:02 PM
Website Feedback:
http://www.uwa.edu.au/117768
Last updated:
Tuesday, 14 July, 2009 1:02 PM
Website Feedback:
http://www.uwa.edu.au/117768
